       Document 0495
 DOCN  M9630495
 TI    Langerhans cells and HIV infection.
 DT    9603
 AU    Zambruno G; Giannetti A; Bertazzoni U; Girolomoni G; Istituto
       Dermopatico dell' Immacolata, IRCCS, Roma, Italy.
 SO    Immunol Today. 1995 Nov;16(11):520-4. Unique Identifier : AIDSLINE
       MED/96084510
 AB    Epidermal Langerhans cells (LCs) isolated from individuals infected with
       human immunodeficiency virus (HIV-1) harbour HIV-1 proviral DNA and RNA,
       indicating productive infection by the virus in vivo. Furthermore,
       normal LCs can be infected in vitro by HIV and can present HIV antigens
       to helper T cells. Here, Giovanna Zambruno and colleagues discuss the
       possibility that LCs of genital mucosae are among the first targets of
       HIV infection following sexual contact, and can be involved both in the
       transmission of the infection to T cells and in T-cell priming to HIV
       antigens. In addition, epidermal LCs might acquire HIV infection from
       dermal T cells during transit from blood vessels through the dermis and
       may, in turn, represent a reservoir of the virus for continued T-cell
       infection.
 DE    Animal  Human  HIV Infections/*PATHOLOGY  *HIV-1  Langerhans
       Cells/*VIROLOGY  Support, Non-U.S. Gov't  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

