       Document 0492
 DOCN  M9630492
 TI    Are HIV-specific CTL responses salutary or pathogenic?
 DT    9603
 AU    Zinkernagel RM; Institute of Experimental Immunology, University of
       Zurich,; Switzerland.
 SO    Curr Opin Immunol. 1995 Aug;7(4):462-70. Unique Identifier : AIDSLINE
       MED/96085782
 AB    Recently, HIV has been shown to be highly variable in patients; it is
       capable of escaping, or even turning off, cytotoxic T-cell responses by
       mutating T-cell epitopes. New antiviral drugs have revealed the enormous
       turnover of C4+ T cells in infected patients, but have also shown how
       efficiently HIV rapidly escapes such treatments. Although HIV is usually
       considered to be cytopathic, this is not really known. The proposal that
       AIDS pathogenesis reflects immunopathological consequences of anti-HIV
       protective CD8+ T cells has to be seriously considered. Such a
       pathogenesis is illustrated by CD8+ T cell mediated immunosuppression
       during acute infection of mice with the non-cytopathic lymphocytic
       choriomeningitis virus.
 DE    Animal  Human  HIV/IMMUNOLOGY/*PATHOGENICITY  HIV
       Infections/*ETIOLOGY/*IMMUNOLOGY/PATHOLOGY  Support, Non-U.S. Gov't
       T-Lymphocytes, Cytotoxic/*IMMUNOLOGY/VIROLOGY  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

