       Document 0489
 DOCN  M9630489
 TI    Immunogenetics in the analysis of resistance to intracellular pathogens.
 DT    9603
 AU    McLeod R; Buschman E; Arbuckle LD; Skamene E; Michael Reese Hospital and
       Medical Center, Chicago, USA.
 SO    Curr Opin Immunol. 1995 Aug;7(4):539-52. Unique Identifier : AIDSLINE
       MED/96085792
 AB    Recent studies have identified genes involved in resistance to
       intracellular pathogens. Such genes include the murine MHC class I gene,
       Ld (toxoplasmosis), HLA-BW53, HLA DRB1* 1302-DQ B10s01 and TNF2
       (malaria), murine Nramp (toxoplasmosis, leishmaniasis and tuberculosis),
       gene(s) modulating the T-helper type 1 and type 2 dichotomy
       (leishmaniasis, leprosy and HIV infection) and the natural killer cell
       complex (cytomegalovirus infection). There also have been other advances
       in immunogenetics that have led to a better understanding of resistance
       to intracellular pathogens. These include effector mechanisms of immune
       response genes and factors modulating genetic susceptibility.
       Identification of genes that determine resistance/susceptibility (and
       their effector mechanisms) has impacted on vaccine development.
       Immunogenetics has been important in characterizing roles of TCR genes,
       superantigens, and host genes that play a role in molecular mimicry in
       disease pathogenesis. In addition, recent work with gene knockout,
       recombinant inbred or congenic, mutant, consomic, and transgenic mice,
       positional cloning, mouse/human gene homologies to identify candidate
       human resistance genes, and the rapid expansion of the gene
       transcription maps of the human genome, have been important in analysis
       of resistance to intracellular pathogens.
 DE    Animal  Human  Immunity, Natural/*GENETICS
       Infection/*GENETICS/*IMMUNOLOGY  Support, Non-U.S. Gov't  Support, U.S.
       Gov't, P.H.S.  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

