       Document 0479
 DOCN  M9630479
 TI    The ontogeny of class-regulation of CD4+ T lymphocyte populations.
 DT    9603
 AU    Carneiro J; Stewart J; Coutinho A; Coutinho G; Unite d'Immunobiologie,
       Institut Pasteur, Paris, France.
 SO    Int Immunol. 1995 Aug;7(8):1265-77. Unique Identifier : AIDSLINE
       MED/96022648
 AB    The differential class-regulation of CD4+ T lymphocyte populations is
       believed to play a major role in determining the qualitative behaviour
       of the immune system, and in the fate of immune responses in particular.
       In this article we propose a model for the dynamics of the Th1 and Th2
       subpopulations. We put forward the concept of an 'antigenic niche' which
       allows us to postulate that the key feature underlying the regulation of
       Th differentiation pathways is the population dynamics of the
       lymphocytes themselves. Using this model we are able to account for a
       number of well established experimental observations which were hitherto
       apparently unrelated and poorly understood. This suggests that our
       simplified model might be capturing some essential features of the
       immune system.
 DE    Animal  *Antigens, CD4  Cell Differentiation/IMMUNOLOGY  Human
       *Lymphocyte Transformation  *Models, Immunological  Support, Non-U.S.
       Gov't  *Th1 Cells/CLASSIFICATION/CYTOLOGY/IMMUNOLOGY  *Th2
       Cells/CLASSIFICATION/CYTOLOGY/IMMUNOLOGY  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

