       Document 0477
 DOCN  M9630477
 TI    Selection of TCR V alpha by MHC class II predicts superantigen
       reactivity.
 DT    9603
 AU    Alam SM; Sim BC; Gascoigne NR; Department of Immunology, Scripps
       Research Institute, La Jolla,; CA 92037, USA.
 SO    Int Immunol. 1995 Aug;7(8):1311-8. Unique Identifier : AIDSLINE
       MED/96022653
 AB    Recognition of superantigens by T cells predominantly involves the TCR V
       beta region. The contribution of reactivity from the non-V beta portion
       of the TCR remains less clear. We have investigated the V alpha
       repertoire of T cells bearing one V beta element responding to different
       superantigen or polyclonal stimuli. The data indicate that the V alpha
       chain is not directly involved in superantigen recognition, since
       unrelated superantigens do not stimulate cells bearing different V alpha
       elements. Instead, analysis of V alpha elements used preferentially in
       the CD4+ or CD8+ cells, shows that the V alpha-regions predominating in
       the superantigen response are the same V alphas that are positively
       selected into the CD4+ lineage. Thus the ability of a V alpha-region to
       either aid or hinder the interaction with class II predicts its
       frequency in a superantigen-responding population of T cells.
 DE    Animal  Antigens, Viral/PHARMACOLOGY  CD4-Positive
       T-Lymphocytes/IMMUNOLOGY  CD8-Positive T-Lymphocytes/IMMUNOLOGY
       Enterotoxins/PHARMACOLOGY  Genes, MHC Class II/*IMMUNOLOGY  Lymphocyte
       Transformation  Mice  Mice, Inbred BALB C  Mice, Inbred C57BL  Mice,
       Transgenic  Receptors, Antigen, T-Cell, alpha-beta/*IMMUNOLOGY
       Retroviridae/IMMUNOLOGY  Staphylococcus aureus/IMMUNOLOGY
       Superantigens/GENETICS/*PHARMACOLOGY  Support, Non-U.S. Gov't  Support,
       U.S. Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

