       Document 0473
 DOCN  M9630473
 TI    Roles of oxygen and photoinduced acidification in the light-dependent
       antiviral activity of hypocrellin A.
 DT    9603
 AU    Fehr MJ; Carpenter SL; Wannemuehler Y; Petrich JW; Department of
       Chemistry, Iowa State University, Ames, USA.
 SO    Biochemistry. 1995 Dec 5;34(48):15845-8. Unique Identifier : AIDSLINE
       MED/96097011
 AB    Hypocrellin A displays photoinduced antiviral activity, in particular
       against the human immunodeficiency virus (HIV), as does its counterpart,
       hypericin. Although hypocrellin A, like hypericin, executes an
       excited-state intramolecular proton transfer, it differs from hypericin
       in two important ways. Unlike hypericin, hypocrellin A absolutely
       requires oxygen for its antiviral activity. Also, whereas we have
       previously demonstrated that hypericin functions as a light-induced
       proton source, we do not observe that hypocrellin A acidifies its
       surrounding medium in the presence of light. These results are discussed
       in the context of the ground- and excited-state photophysics of
       hypericin and its mechanisms of photoinduced virucidal activity.
 DE    Antiviral Agents/CHEMISTRY/*PHARMACOLOGY  Hydrogen-Ion Concentration
       HIV/DRUG EFFECTS  *Light  Oxygen/*METABOLISM  Perylene/*ANALOGS &
       DERIVATIVES/CHEMISTRY/PHARMACOLOGY  Photochemistry
       Quinones/CHEMISTRY/*PHARMACOLOGY  Support, Non-U.S. Gov't  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

