       Document 0467
 DOCN  M9630467
 TI    High purity factor VIII concentrates for the treatment of HIV-positive
       patients with haemophilia.
 DT    9603
 AU    Sultan Y; Centre de l'Accueil et de Traitement des Hemophiles, Hopital;
       Chochin, Paris, France.
 SO    Blood Coagul Fibrinolysis. 1995 Jul;6 Suppl 2:S80-1. Unique Identifier :
       AIDSLINE MED/96076204
 AB    Some factor VIII concentrates cause downregulation of the immune system
       in HIV-positive haemophilia patients. This effect appears to be related
       to the purity of the concentrate, but not to its method of preparation.
       The optimum purity for preventing downregulation is not known at
       present.
 DE    Adolescence  Adult  Chromatography, Ion Exchange  CD4 Lymphocyte Count
       Down-Regulation (Physiology)  Factor VIII/ADVERSE EFFECTS/*ISOLATION &
       PURIF  Hemophilia/*COMPLICATIONS  Human  HIV Seropositivity/*DRUG
       THERAPY/IMMUNOLOGY  Middle Age  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

