       Document 0457
 DOCN  M9630457
 TI    Clinical features of HIV seropositive and HIV seronegative patients with
       tuberculous lymphadenitis in Dar es Salaam.
 DT    9603
 AU    Perenboom RM; Richter C; Swai AB; Kitinya J; Mtoni I; Chande H; Kazema
       RR; Department of Medicine, Muhimbili Medical Centre, Dar es Salaam,;
       Tanzania.
 SO    Tuber Lung Dis. 1995 Oct;76(5):401-6. Unique Identifier : AIDSLINE
       MED/96091563
 AB    SETTING: The medical wards of a referral hospital in Dar es Salaam,
       Tanzania. OBJECTIVE: To investigate the impact of HIV infection on
       clinical features in tuberculous lymphadenitis. DESIGN: A prospective
       clinical study of HIV seropositive and HIV seronegative patients with
       lymphadenopathy. RESULTS: Of 128 patients with peripheral
       lymphadenopathy, 24 had no tuberculosis (TB) and in 10 patients TB was
       found only in other organs. The remaining 94 patients, of whom 76% were
       HIV seropositive, formed our study population. TB lymphadenitis was
       considered proven in 89 and probable in 5 patients. Disseminated TB
       (both TB adenitis and TB in other organs) was diagnosed more often in
       HIV seropositive than in HIV seronegative patients (52% versus 26%, P <
       0.03). 59% of the 71 HIV-infected patients compared to only 4% of the 23
       patients without HIV infection were over 30 years of age (P < 0.02). The
       following clinical features were significantly associated with HIV
       infection: dyspnoea, respiratory rate > 20/min, low motility score
       (bedridden), neurological abnormalities, hepatomegaly, splenomegaly,
       lymph node size < 2.5 cm, negative PPD skin test, lymphopenia (<
       1000/cm3) and presence of pleural fluid. CONCLUSION: Co-infection with
       HIV influences several clinical and laboratory features in patients with
       tuberculous lymphadenitis.
 DE    Adult  Human  *HIV Seronegativity  HIV
       Seropositivity/*COMPLICATIONS/PATHOLOGY/RADIOGRAPHY  Lymph
       Nodes/PATHOLOGY  Pleural Effusion/RADIOGRAPHY  Prospective Studies
       Support, Non-U.S. Gov't  Tuberculosis, Lymph
       Node/*COMPLICATIONS/DIAGNOSIS/RADIOGRAPHY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

