       Document 0450
 DOCN  M9630450
 TI    Glycoforms of serum alpha 1-acid glycoprotein as markers of inflammation
       and cancer.
 DT    9603
 AU    Mackiewicz A; Mackiewicz K; Department of Cancer Immunology, University
       School of Medical; Sciences, Great Poland Cancer Center, Poznan.
 SO    Glycoconj J. 1995 Jun;12(3):241-7. Unique Identifier : AIDSLINE
       MED/96121946
 AB    alpha 1-acid glycoprotein (AGP) is a serum acute phase glycoprotein
       which possesses five N-linked complex type heteroglycan side chains
       which may be present as bi-, tri- and tetraantennary structures.
       Depending upon the content of biantennary structure on AGP, up to four
       glycoforms of AGP are present in serum. These glycoforms can be easily
       estimated in body fluids by means of crossed
       affinity-immunoelectrophoresis (CAIE) with the lectin, Concanavalin A
       (Con A). Con A selectively binds biantennary structures; the more
       biantennary structures on AGP, the stronger the binding. In acute
       inflammation, a relative increase of AGP glycoforms with biantennary
       units is observed-a type I glycosylation change. In some chronic
       inflammatory states there is an relative decrease of AGP glycoforms with
       biantennary heteroglycans-a type II glycosylation change. Moreover, in
       certain other states such as pregnancy, estrogen administration or liver
       damage, type II glycosylation changes are also seen. A detailed analysis
       of the clinical applications of the assessment of AGP glycoforms in sera
       of patients with rheumatic diseases, AIDS and various types of cancers
       is presented. Accumulated data shows that AGP glycoforms may be very
       useful in the detection of intercurrent infections in the course of
       rheumatoid arthritis, systemic lupus erythematosus, or myeloblastic
       leukaemia, and in the detection of secondary infections in human
       immunodeficiency virus infected individuals. AGP glycoforms are also
       very useful in differentiation between various forms of trophoblastic
       disease and are helpful in monitoring the treatment of these patients.
       Finally, AGP glycoforms provide valuable information for differentiation
       between primary and secondary liver cancer.
 DE    Acquired Immunodeficiency Syndrome/BLOOD  Biological Markers/CHEMISTRY
       Human  Inflammation/*BLOOD  Neoplasm Proteins/*CHEMISTRY/METABOLISM
       Neoplasms/BLOOD/CHEMISTRY  Orosomucoid/*CHEMISTRY/METABOLISM  Rheumatic
       Diseases/BLOOD  Support, Non-U.S. Gov't  Tumor Markers,
       Biological/*BLOOD  JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

