       Document 0448
 DOCN  M9630448
 TI    A new approach for the pathogenesis of human African trypanosomiasis.
 DT    9603
 AU    Kristensson K; Eneroth A; Olsson T; Wiesenfeld-Hallin Z; Department of
       Neuroscience, Karolinska Institutet, Stockholm,; Sweden.
 SO    Bull Soc Pathol Exot. 1994;87(5):319-22. Unique Identifier : AIDSLINE
       MED/96091677
 AB    From Trypanosoma brucei brucei, a molecule has been isolated which
       triggers the production of IFN-gamma by CD8+ T-cells. IFN-gamma
       modulates events in the hosts immune- and nervous system and provides a
       growth stimulus for the parasites. Furthermore, a molecule with
       IFN-gamma-like immunoreactivity has been detected in rat dorsal root
       ganglion cells and certain neurons in the brain. This neuron-derived
       IFN-gamma-like molecule differs in molecular weight from
       lymphocyte-derived IFN-gamma but shares important biological activities
       with the latter, which includes a growth stimulus for trypanosomes.
       Trypanosomes localized to sensory ganglia and infected rats develop a
       severe thermal hyperalgesia. Intrathecal injection of IFN-gamma causes
       in rats a sustained phase of nociceptive flexor reflex facilitation,
       which can be partially blocked by nitro-L-arginin-ester, an inhibitor of
       nitric oxide synthase, indicating that nociceptive effects of the
       IFN-gamma is mediated by activation of the L-arginin-nitric oxide
       pathway.
 DE    Animal  Arginine/ANALOGS & DERIVATIVES/PHARMACOLOGY  Brain/METABOLISM
       CD8-Positive T-Lymphocytes/METABOLISM  Disease Models, Animal  Enzyme
       Inhibitors/PHARMACOLOGY  Ganglia, Sensory/PARASITOLOGY  Ganglia,
       Spinal/METABOLISM/PARASITOLOGY  Growth Substances/BIOSYNTHESIS  Heat
       Human  Hyperalgesia/ETIOLOGY  Injections, Spinal  Interferon Type
       II/ADMINISTRATION & DOSAGE/BIOSYNTHESIS/  PHARMACOLOGY  Mice
       Neurons/METABOLISM  Nitric-Oxide Synthase/ANTAGONISTS & INHIB
       Nociceptors/DRUG EFFECTS  Rats  Support, Non-U.S. Gov't  Trypanosoma
       brucei brucei/METABOLISM/PHYSIOLOGY  Trypanosomiasis, African/*ETIOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

