       Document 0446
 DOCN  M9630446
 TI    The origins of Hodgkin's disease.
 DT    9603
 AU    Michels KB; Department of Epidemiology, Harvard School of Public
       Health,; Boston, MA 02115, USA.
 SO    Eur J Cancer Prev. 1995 Oct;4(5):379-88. Unique Identifier : AIDSLINE
       MED/96098433
 AB    Despite significant advances in treatment, the aetiology of Hodgkin's
       disease has remained elusive. While epidemiology has uncovered the
       likely infectious nature of the malignancy, neither the causative agent
       nor the cell of origin have been identified. The available
       epidemiological, histological and molecular biological evidence were
       reviewed and the following conclusions reached. Hodgkin's disease is
       probably an infectious, but not contagious disease, and is compounded by
       immunodeficiency. The suspected role of the Epstein-Barr virus (EBV) as
       causative agent has been substantially weakened, although a role as
       co-factor is likely. A prime candidate for the cell of origin seems the
       interdigitating reticulum cell (IRC). Reed-Sternberg cells found in
       patients with Hodgkin's disease may represent in vivo hybridomas of the
       IRC with B- and/or T-cells. As IRC is unlikely to be susceptible to EBV,
       a retrovirus may be the culprit. Hybridomas may be formed when
       retroviral antigens expressed by a macrophage cell attract reactive B-
       and T-cells and, instead of an immune reaction, fusion occurs. Further
       research is necessary in the search for the causative agent of Hodgkin's
       disease.
 DE    Antigens, Viral/IMMUNOLOGY  B-Lymphocytes/PATHOLOGY  Cocarcinogenesis
       Herpesviridae Infections  Herpesvirus 4, Human/PHYSIOLOGY  Hodgkin's
       Disease/*ETIOLOGY/GENETICS/IMMUNOLOGY/PATHOLOGY/  VIROLOGY  Human
       Hybridomas  Immunologic Deficiency Syndromes  Macrophages/IMMUNOLOGY
       Reed-Sternberg Cells/PATHOLOGY  Reticuloendothelial System/PATHOLOGY
       Retroviridae  Retroviridae Infections  T-Lymphocytes/PATHOLOGY  Tumor
       Stem Cells/PATHOLOGY  Tumor Virus Infections  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

