       Document 0435
 DOCN  M9630435
 TI    Persistent generalized lymphadenopathy and non-Hodgkin's lymphoma in
       AIDS: association with Rochalimaea henselae infection.
 DT    9603
 AU    Peter JB; Boyle M; Patnaik M; Hadfield TL; Barka NE; Schwartzman WA;
       Penny RS; Specialty Laboratories, Inc., Santa Monica, California 90404,;
       USA.
 SO    Clin Diagn Lab Immunol. 1994 Jan;1(1):115-6. Unique Identifier :
       AIDSLINE MED/96050790
 AB    Cat scratch disease, which is caused by infection with Rochalimaea
       henselae, is often manifested as lymphadenopathy. R. henselae has also
       been isolated from human immunodeficiency virus (HIV)-positive patients
       with bacillary angiomatosis. In order to determine the frequency of R.
       henselae-reactive antibodies in HIV-positive patients with persistent
       generalized lymphadenopathy (PGL) or non-Hodgkin's lymphoma (NHL), we
       tested a total of 124 HIV-positive patients for R. henselae-reactive
       immunoglobulin G (IgG), IgM, and IgA antibodies by an enzyme immunoassay
       procedure using whole R. henselae antigen. Of the patients, 7 had PGL,
       17 had NHL, and 100 were HIV stage IV (Centers for Disease Control
       criteria). A total of 86% of PGL patients (6 of 7) were positive for R.
       henselae antibodies (three were positive for IgG, IgA, and IgM, one was
       positive for IgG and IgA only, and two were positive for IgG only). A
       total of 29% of NHL patients (5 of 17) were positive for R. henselae
       antibodies (two were positive for IgG, IgA, and IgM and three were
       positive for IgG only). Only 5% of HIV Stage IV patients without
       adenopathy (5 of 100) were positive for R. henselae-reactive IgG, IgA,
       and IgM. The high prevalence of R. henselae-reactive antibodies in
       HIV-positive PGL and NHL patients suggests that R. henselae is a
       potential etiologic agent or cofactor in these patients.
 DE    Angiomatosis, Bacillary/IMMUNOLOGY  Antibodies, Bacterial/BLOOD
       AIDS-Related Complex/*IMMUNOLOGY  Bartonella henselae/*IMMUNOLOGY
       Cat-Scratch Disease/*IMMUNOLOGY  Human  Lymphoma,
       Non-Hodgkin's/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

