       Document 0432
 DOCN  M9630432
 TI    Immunologic cross-reactivity between structural proteins of human T-cell
       lymphotropic virus type I and the blood stage of Plasmodium falciparum.
 DT    9603
 AU    Lal RB; Rudolph D; Alpers MP; Sulzer AJ; Shi YP; Lal AA; Retrovirus
       Diseases Branch, Centers for Disease Control and; Prevention, Atlanta,
       Georgia 30333, USA.
 SO    Clin Diagn Lab Immunol. 1994 Jan;1(1):5-10. Unique Identifier : AIDSLINE
       MED/96050770
 AB    To determine the serologic cross-reactivity between human T-cell
       lymphotropic virus type I (HTLV-I) and parasite antigens, we measured
       antibody responses against HTLV-I, Plasmodium falciparum, Plasmodium
       vivax, and Brugia malayi in serum specimens obtained from regions where
       malaria (n = 482) and filariasis (n = 101) are endemic. Analysis of
       immune reactivity to HTLV-I antigens showed that specimens from regions
       where malaria is endemic had significantly higher rates of enzyme
       immunoassay (EIA) reactivity (76 of 482 [15.8%] than those from regions
       where filariasis is endemic (0 of 101 [0%]). Western blot (immunoblot)
       analysis of the HTLV-I EIA-reactive specimens demonstrated predominant
       Gag reactivity (HTLV-Iind). Only two specimens each from Indonesia and
       Brazil and four specimens from Papua New Guinea had Env reactivity by
       radioimmunoprecipitation analysis. Furthermore, a positive correlation
       between HTLV-EIA and titers of antibody to the blood stage of P.
       falciparum (rs = 0.24, P < 0.005) was discerned; no correlation was
       observed between antibodies to the blood stage or the circumsporozoite
       protein of P. vivax and the circumsporozoite protein of P. falciparum.
       In addition, P. falciparum-infected erythrocyte lysate specifically
       abrogated binding of Gag-specific antibodies in HTLV-Iind specimens from
       regions where malaria is endemic without affecting binding in
       HTLV-I-seropositive specimens, suggesting that the immunologic
       cross-reactivity between HTLV Gag proteins and malaria parasites is
       restricted to the blood-stage antigens of plasmodia in specimens from
       regions where malaria is endemic.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Animal  Antigens, Protozoan/BLOOD/*IMMUNOLOGY  Binding Sites, Antibody
       Binding, Competitive/IMMUNOLOGY  Cross Reactions
       Erythrocytes/IMMUNOLOGY  Human  HTLV-I Antibodies/BLOOD  Malaria,
       Falciparum/*BLOOD/IMMUNOLOGY/PARASITOLOGY  Plasmodium falciparum/GROWTH
       & DEVELOPMENT/*IMMUNOLOGY  Viral Structural Proteins/BLOOD/*IMMUNOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

