       Document 0431
 DOCN  M9630431
 TI    Clinical significance of serum 2,5-oligoadenylate synthetase and soluble
       interleukin-2 receptor in hemophiliacs positive and negative for human
       immunodeficiency virus type 1.
 DT    9603
 AU    Matsuda J; Gotoh M; Gohchi K; Tsukamoto M; Saitoh N; Kinoshita T;
       Department of Medicine, Teikyo University School of Medicine,; Tokyo,
       Japan.
 SO    Clin Diagn Lab Immunol. 1994 Mar;1(2):155-9. Unique Identifier :
       AIDSLINE MED/96050798
 AB    We measured serum 2,5-oligoadenylate synthetase (2,5-AS) levels and
       soluble interleukin-2 receptor (sIL-2R) levels in human immune
       deficiency virus type 1 (HIV-1)-positive and HIV-1-negative hemophiliacs
       in order to clarify the clinical significance of these parameters in
       hemophiliacs. Serum 2,5-AS levels were measured by a radioimmunosorbent
       assay, and sIL-2R levels were measured by an enzyme-linked immunosorbent
       assay. The mean serum 2,5-AS levels were higher in AIDS-related-complex
       and AIDS patients, asymptomatic carriers, and HIV-1-negative
       hemophiliacs than in hepatitis C virus-positive patients and healthy
       controls. Serial determinations showed that the 2,5-AS levels tended to
       increase in HIV-1-positive patients, especially those with AIDS-related
       complex or AIDS, although it showed a substantial decrease in the
       terminal stage. The serum sIL-2R levels were higher in HIV-1-positive
       patients, HIV-1-negative patients, and hepatitis C virus-positive
       patients than in controls. Serial studies showed little change in the
       HIV-1-positive and HIV-1-negative groups, although sIL-2R levels showed
       a tendency to decrease with zidovudine treatment. On the basis of the
       present results, we may well conclude that 2,5-AS and sIL-2R are not
       specific markers for hemophiliacs with HIV-1 infection. However, serial
       measurement of these markers can still be useful for assessing the
       progression of AIDS and the prognosis for patients with AIDS, as well as
       for monitoring the response to zidovudine.
 DE    Adolescence  Adult  Biological Markers/BLOOD
       Hemophilia/*ENZYMOLOGY/IMMUNOLOGY  Hepatitis C/ENZYMOLOGY/IMMUNOLOGY
       Human  HIV Seronegativity/*IMMUNOLOGY  HIV Seropositivity/DRUG
       THERAPY/*ENZYMOLOGY/IMMUNOLOGY  Middle Age  Receptors,
       Interleukin-2/*ANALYSIS  Support, Non-U.S. Gov't  Zidovudine/THERAPEUTIC
       USE  2',5'-Oligoadenylate Synthetase/*BLOOD  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

