       Document 0386
 DOCN  M9630386
 TI    Cerebral tuberculoma--a comparative study in patients with and without
       HIV infection.
 DT    9603
 AU    Martinez-Vazquez C; Bordon J; Rodriguez-Gonzalez A; de la Fuente-Aguado
       J; Sopena B; Gallego-Rivera A; Martinez-Cueto P; Infectious Disease
       Unit, Hospital Xeral of Vigo Medical School of; Santiago de Compostela
       University, Spain.
 SO    Infection. 1995 May-Jun;23(3):149-53. Unique Identifier : AIDSLINE
       MED/96121812
 AB    The microbiological, clinical and radiological findings of cerebral
       tuberculomas in four patients with and in five patients without HIV
       infection were compared. The study was carried out during the last 14
       years. The CT scans were analyzed in a blinded fashion. Cerebral
       tuberculoma in HIV-negative patients was clinically characterized by
       seizures, while in HIV-positive patients this finding was absent. All
       four HIV-infected patients had headache and fever and their CSF showed
       lymphocytic meningitis. Two HIV-negative and three HIV-positive patients
       had concurrent extracerebral tuberculosis. In HIV-infected patients, the
       cerebral tuberculoma was a secondary finding of disseminated
       tuberculosis. In our small patient samples, the cerebral tuberculoma
       presented as spontaneous hypodense cerebral lesions in all the
       HIV-positive patients but as a hyperdense cerebral lesion in the
       HIV-negative patients. Two patients of each group had ring enhancement
       lesions. Cerebral tuberculoma was diagnosed in about 4 weeks for
       HIV-positive patients, but took some 16 weeks for HIV-negative patients,
       the latter being first suspected of having a cerebral tumor or bacterial
       abscess. Diagnostic craniotomy was thus necessary for the HIV-negative
       patients. One patient of each group died as a consequence of cerebral
       tuberculoma, all the remaining patients improved with treatment.
 DE    Adult  Antitubercular Agents/THERAPEUTIC USE
       Brain/PATHOLOGY/RADIOGRAPHY  Case-Control Studies  Cerebrospinal
       Fluid/MICROBIOLOGY  Comparative Study  Female  Fever/ETIOLOGY
       Headache/ETIOLOGY  Human  HIV Infections/*COMPLICATIONS  *HIV
       Seronegativity  Male  Meningitis, Bacterial/ETIOLOGY  Middle Age
       Mycobacterium tuberculosis/ISOLATION & PURIF  Seizures/ETIOLOGY
       Tomography, X-Ray Computed  Tuberculoma, Intracranial/DRUG
       THERAPY/*ETIOLOGY/RADIOGRAPHY  Tuberculosis, Pulmonary/COMPLICATIONS
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

