       Document 0382
 DOCN  M9630382
 TI    Hot water extracts of Chlorella vulgaris reduce opportunistic infection
       with Listeria monocytogenes in C57BL/6 mice infected with LP-BM5 murine
       leukemia viruses.
 DT    9603
 AU    Hasegawa T; Okuda M; Makino M; Hiromatsu K; Nomoto K; Yoshikai Y;
       Laboratory of Host Defense and Germfree Life, Nagoya University; School
       of Medicine, Japan.
 SO    Int J Immunopharmacol. 1995 Jun;17(6):505-12. Unique Identifier :
       AIDSLINE MED/96022699
 AB    The bacterial elimination after infection with Listeria monocytogenes
       was impaired in mice with murine acquired immunodeficiency syndrome
       (MAIDS) by infection with LP-BM5 murine leukemia virus. Oral
       administration of hot water extracts of Chlorella vulgaris (CVE)
       restored the capacity of MAIDS mice to eliminate L. monocytogenes in
       association with improvement of the deteriorated immune response to L.
       monocytogenes. DTH response to Listeria in CVE-treated MAIDS mice was
       significantly higher than that of MAIDS mice after Listeria infection in
       association with increases in number of CD4+CD8- and CD4-CD8+ alpha beta
       T-cells in the infected sites. CVE might be effective in the treatment
       of opportunistic infection in retrovirus-induced immunodeficient
       patients.
 DE    Animal  Chlorella/*CHEMISTRY  Female  Hypersensitivity,
       Delayed/IMMUNOLOGY  *Leukemia Viruses, Murine/DRUG EFFECTS  Leukemia,
       Experimental/COMPLICATIONS  Listeria monocytogenes/GROWTH &
       DEVELOPMENT/IMMUNOLOGY  Listeria
       Infections/COMPLICATIONS/IMMUNOLOGY/*PREVENTION &  CONTROL  Mice  Mice,
       Inbred C57BL  Murine Acquired Immunodeficiency Syndrome/COMPLICATIONS
       Opportunistic Infections/COMPLICATIONS/IMMUNOLOGY/*PREVENTION &  CONTROL
       Plant Extracts/*THERAPEUTIC USE  T-Lymphocytes/DRUG EFFECTS/IMMUNOLOGY
       Tumor Virus Infections/COMPLICATIONS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

