       Document 0381
 DOCN  M9630381
 TI    Mathematical modelling of HIV infection therapy.
 DT    9603
 AU    Hraba T; Dolezal J; Institute of Molecular Genetics, Academy of Sciences
       of the Czech; Republic, Prague, Czech Republic.
 SO    Int J Immunopharmacol. 1995 Jun;17(6):523-6. Unique Identifier :
       AIDSLINE MED/96022702
 AB    The previously developed mathematical model simulates the CD4+
       lymphocyte dynamics in HIV infection very well. As the number of these
       cells is a good indicator of the infection progression, it was used to
       evaluate the effectiveness of different therapeutic interventions. For
       chemotherapy simulation, both permanent and temporary zinovudine (AZT)
       administration were considered and the induced return of the CD4+
       lymphocyte counts was analysed. Similar analysis was performed for
       active and passive immunotherapy. The model offers also the possibility
       of stimulating the CD4+ dynamics after depletion of CD8+ lymphocytes by
       antibodies. Even one simulated administration of anti-CD8 antibodies
       increases the CD4+ lymphocyte counts and prolongs the survival of the
       patient. However, if cells involved in protective immunity are assumed
       to belong to the CD8+ category, anti-CD8 antibodies accelerate the
       decrease of CD4- cells and thus shorten the patient's survival.
 DE    CD4-Positive T-Lymphocytes/*IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/IMMUNOLOGY  Human  HIV Infections/IMMUNOLOGY/*THERAPY
       Lymphocyte Depletion  Models, Theoretical  Zidovudine/*THERAPEUTIC USE
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

