       Document 0368
 DOCN  M9630368
 TI    Virus-activated T cells regulate expression of adhesion molecules on
       endothelial cells in sites of infection.
 DT    9603
 AU    Marker O; Scheynius A; Christensen JP; Thomsen AR; Institute of Medical
       Microbiology and Immunology, University of; Copenhagen, Panum Institute,
       Denmark.
 SO    J Neuroimmunol. 1995 Oct;62(1):35-42. Unique Identifier : AIDSLINE
       MED/96084980
 AB    To study the role of cell adhesion molecules in the fatal CD8+ T-cell
       mediated meningitis which is induced by intracerebral infection with
       lymphocytic choriomeningitis virus, the expression of relevant molecules
       on inflammatory cells and local endothelium was analyzed
       immunohistochemically. Most inflammatory cells were strongly positive
       for LFA-1, VLA-4, Pgp-1 and ICAM-1. Expression of ICAM-1 and VCAM-1 was
       upregulated on the endothelial cells in immunocompetent mice, but not in
       T-cell deficient nude mice. Analysis of mice deficient in either CD4+ or
       CD8+ T cells, revealed that not only was the inflammatory reaction
       dependent on the presence of CD8+ cells, but these cells also appeared
       to be required for maximal upregulation of ICAM-1 and VCAM-1 on the
       endothelial cells. These results indicate that virus-specific CD8+ T
       cells are crucially involved in regulating the inflammatory reaction
       through effects on endothelial expression of adhesion molecules.
 DE    Animal  Choroid Plexus/IMMUNOLOGY/VIROLOGY  CD8-Positive
       T-Lymphocytes/*VIROLOGY  Endothelium/IMMUNOLOGY/VIROLOGY  Female  Gene
       Expression Regulation, Viral/IMMUNOLOGY  Histocompatibility Antigens
       Class I/PHYSIOLOGY  Histocompatibility Antigens Class II/PHYSIOLOGY
       Immunohistochemistry  Intercellular Adhesion Molecule-1/*IMMUNOLOGY
       Lymphocytic Choriomeningitis Virus/IMMUNOLOGY
       Meninges/IMMUNOLOGY/VIROLOGY  Meningitis/IMMUNOLOGY/VIROLOGY  Mice
       Mice, Inbred BALB C  Mice, Inbred C57BL  Mice, Nude  Vascular Cell
       Adhesion Molecule-1/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

