       Document 0362
 DOCN  M9630362
 TI    Association of interleukin-2 and interferon-gamma production by blood
       mononuclear cells in infancy with parental allergy skin tests and with
       subsequent development of atopy.
 DT    9603
 AU    Martinez FD; Stern DA; Wright AL; Holberg CJ; Taussig LM; Halonen M;
       Respiratory Sciences Center (Westend Laboratories), University of;
       Arizona HSC, Tucson 85724, USA.
 SO    J Allergy Clin Immunol. 1995 Nov;96(5 Pt 1):652-60. Unique Identifier :
       AIDSLINE MED/96080207
 AB    The mechanisms regulating the onset of atopic sensitization in human
       beings are not yet fully clarified. We assessed the capacity of
       mitogen-stimulated umbilical and peripheral blood mononuclear cells to
       produce interferon-gamma (IFN-gamma) and interleukin-2 (IL-2) at birth
       and at 9 months of age in 159 infants. Mononuclear cell production of
       both IFN-gamma and IL-2 at 9 months, but not at birth, was found to be
       inversely related to parental immediate skin test reactivity to seven
       local aeroallergens. Skin test reactivity at the age of 6 years was also
       inversely related to IFN-gamma and IL-2 production at 9 months of age.
       However, no relationship was evident between total serum IgE levels at 6
       years and production of these cytokines at 9 months. The proportions of
       circulating lymphocytes and CD4+ or CD8+ cells were also unrelated to
       skin test reactivity at the age of 6 years. These data suggest that
       mechanisms regulating skin test reactivity to inhaled allergens may
       involve deficient IFN-gamma production, deficient IL-2 production, or
       both during or preceding the time of initial sensitization and that
       additional mechanisms are involved in regulating total serum IgE level.
 DE    Adult  Allergens/ADVERSE EFFECTS  CD4-Positive T-Lymphocytes/IMMUNOLOGY
       CD8-Positive T-Lymphocytes/IMMUNOLOGY  Dermatitis,
       Atopic/DIAGNOSIS/*ETIOLOGY  Female  Fetal Blood/CYTOLOGY  Follow-Up
       Studies  Human  IgE/IMMUNOLOGY  Infant, Newborn  Interferon Type
       II/*BIOSYNTHESIS  Interleukin-2/*BIOSYNTHESIS  Leukocytes,
       Mononuclear/CYTOLOGY/*METABOLISM  Longitudinal Studies  Male
       Rhinitis/DIAGNOSIS/*ETIOLOGY  Skin Tests  Support, U.S. Gov't, P.H.S.
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

