       Document 0347
 DOCN  M9630347
 TI    Vitamin E supplementation with interferon-gamma administration retards
       immune dysfunction during murine retrovirus infection.
 DT    9603
 AU    Wang JY; Liang B; Watson RR; Department of Family and Community
       Medicine, University of; Arizona, Tucson 85724, USA.
 SO    J Leukoc Biol. 1995 Dec;58(6):698-703. Unique Identifier : AIDSLINE
       MED/96107363
 AB    Murine retrovirus infection induces loss of vitamin E and immune
       dysfunction with loss of cytokine production by T-helper cells.
       Therefore interferon-gamma (IFN-gamma) was given during dietary vitamin
       E supplementation to effectively prevent murine retrovirus-induced
       immunosuppression, cytokine dysregulation, and development of murine
       AIDS. Administration of IFN-gamma during vitamin E supplementation
       significantly prevented development of retrovirus-induced suppression of
       splenic natural killer cell activity and T cell proliferation. It also
       significantly slowed retrovirus-induced elevation of T helper (Th) 2
       cytokine [interleukin (IL)-4, IL-5, and IL-10] production and monokine
       (IL-6 and tumor necrosis factor-alpha) secretion by splenocytes. The
       treatment also prevented loss of Th1 cytokine (IL-2 and IFN-gamma)
       secretion by splenocytes from retrovirus-infected mice alleviating
       splenomegaly and hypergammaglobulinemia. The combined therapy had an
       additive therapeutic impact. It was more effective than IFN-gamma
       treatment or vitamin E supplementation alone in delaying the development
       of retrovirus-induced immunosuppression with its cytokine dysregulation.
 DE    Animal  B-Lymphocytes/DRUG EFFECTS/IMMUNOLOGY  Cytokines/BIOSYNTHESIS
       Female  Immune Tolerance/DRUG EFFECTS  Interferon Type II/*PHARMACOLOGY
       Killer Cells, Natural/DRUG EFFECTS/IMMUNOLOGY  Lymphocyte
       Transformation/DRUG EFFECTS  Mice  Mice, Inbred C57BL  Murine Acquired
       Immunodeficiency Syndrome/*IMMUNOLOGY  Support, U.S. Gov't, P.H.S.
       Vitamin E/METABOLISM/*PHARMACOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

