       Document 0335
 DOCN  M9630335
 TI    Gamma delta T lymphocytes in human periodontal disease tissue.
 DT    9603
 AU    Gemmell E; Seymour GJ; Department of Dentistry, University of
       Queensland, Australia.
 SO    J Periodontol. 1995 Sep;66(9):780-5. Unique Identifier : AIDSLINE
       MED/96098587
 AB    Gamma delta T cells have been implicated as playing a role in
       inflammatory and autoimmune conditions. In this study, a
       biotin-streptavidin peroxidase technique was used to determine the
       presence of T cells expressing alpha beta and gamma delta T cell
       receptors (TCR) in the inflammatory infiltrates of gingival tissue
       sections from gingivitis and adult periodontitis patients. The lesions
       were graded 1+ to 3+ according to the size of the infiltrate. alpha
       beta+ T cells predominated in all infiltrates with no differences in the
       mean percent (20 to 30%) according to size of lesion or to clinical
       status. A mean percent gamma delta T cells of 0.42 +/- 0.11 and 0.91 +/-
       0.42 was demonstrated in 1+ infiltrates of gingivitis and adult
       periodontitis sections respectively. Although the mean percent gamma
       delta T cells increased in both gingivitis (2.09 +/- 0.54) and adult
       periodontitis sections (2.25 +/- 0.35) with increasing size of
       infiltrate, this was not statistically significant. However, when the
       mean proportion of gamma delta T cells of the total TCR bearing cells
       was determined, there was a significant 3 to 4 fold increase in adult
       periodontitis sections from 3.09 +/- 1.35 in 1+ lesions to 11.90 +/-
       2.94 and 8.81 +/- 1.45 in 2+ and 3+ lesions respectively. A similar
       increase of the same magnitude occurred in gingivitis sections from 2.82
       +/- 0.74 in 1+ lesions to 11.12 +/- 4.13 in 2+ lesions, but this was not
       significant (P = 0.055). There was no correlation between the increase
       in the proportion of gamma delta T cells and the T:B cell ratio or the
       CD4:CD8 ratio in individual lesions.(ABSTRACT TRUNCATED AT 250 WORDS)
 DE    Adult  B-Lymphocytes/IMMUNOLOGY/PATHOLOGY  Cell Count  Comparative Study
       CD4-CD8 Ratio  Gingival Hemorrhage/IMMUNOLOGY/PATHOLOGY
       Gingivitis/IMMUNOLOGY/*PATHOLOGY  Human  Immunoenzyme Techniques
       Periodontal Attachment Loss/IMMUNOLOGY/PATHOLOGY
       Periodontitis/IMMUNOLOGY/*PATHOLOGY  Receptors, Antigen, T-Cell,
       alpha-beta/ANALYSIS  Receptors, Antigen, T-Cell, gamma-delta/*ANALYSIS
       Support, Non-U.S. Gov't  T-Lymphocytes/IMMUNOLOGY/*PATHOLOGY
       Tonsil/IMMUNOLOGY/PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

