       Document 0323
 DOCN  M9630323
 TI    Crystal structure of SIV matrix antigen and implications for virus
       assembly.
 DT    9603
 AU    Rao Z; Belyaev AS; Fry E; Roy P; Jones IM; Stuart DI; Laboratory of
       Molecular Biophysics, Oxford, UK.
 SO    Nature. 1995 Dec 14;378(6558):743-7. Unique Identifier : AIDSLINE
       MED/96107318
 AB    Simian immunodeficiency virus (SIV) is closely related to human
       immunodeficiency virus (HIV), their matrix antigens (MAs) sharing some
       50% sequence identity. MA is a component of Pr55Gag, the sole protein
       required for assembly of the virion shell. MA targets Pr55 to the plasma
       membrane, and facilitates incorporation of the virus envelope protein
       and assembly of the Pr55Gag shell. Cleavage of Pr55 by the viral
       protease produces the mature protein of relative molecular mass 17-18K,
       which underlies the host-derived membrane and is important in both virus
       entry and nuclear localization of the virion core. Here we report the
       crystal structure of SIV MA. The molecule forms a trimer consistent with
       oligomerization in vitro, the observed virion architecture, and various
       biological properties of MA.
 DE    Amino Acid Sequence  Antigens, Viral/*CHEMISTRY/PHYSIOLOGY  Computer
       Graphics  Crystallography, X-Ray  Gene Products,
       gag/*CHEMISTRY/PHYSIOLOGY  Models, Molecular  Molecular Sequence Data
       Protein Conformation  Support, Non-U.S. Gov't  SIV/*CHEMISTRY/PHYSIOLOGY
       Viral Matrix Proteins/*CHEMISTRY/PHYSIOLOGY  Virus Replication  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

