       Document 0319
 DOCN  M9630319
 TI    Prospective cohort study of the effect of pregnancy on the progression
       of human immunodeficiency virus infection. The Groupe d'Epidemiologie
       Clinique Du SIDA en Aquitaine.
 DT    9603
 AU    Hocke C; Morlat P; Chene G; Dequae L; Dabis F; Service de
       Gynecologie-Obstetrique, Hopital Pellegrin, Centre; Hospitalier
       Universitaire, Bordeaux, France.
 SO    Obstet Gynecol. 1995 Dec;86(6):886-91. Unique Identifier : AIDSLINE
       MED/96072912
 AB    OBJECTIVE: To study the prognostic role of pregnancy on the progression
       of human immunodeficiency virus (HIV) infection. METHODS: In a
       prospective cohort study at the Bordeaux University Hospital, France, 57
       women who completed a pregnancy during the course of their HIV infection
       were compared with 114 HIV-infected women who never conceived. The two
       groups were matched on CD4 lymphocyte count (CD4), age, and year of HIV
       diagnosis. The main outcome measures were death, occurrence of a first
       AIDS-defining event, and drop of the CD4 below 200/mm3. RESULTS: The
       mean follow-up period in pregnant women was 61 months from HIV diagnosis
       (median CD4 at entry 455/mm3) and 54 months from beginning of pregnancy.
       Nonpregnant women were followed-up for 50 months since HIV diagnosis
       (median CD4 460/mm3). The proportion of asymptomatic women at entry in
       the study was 51 of 57 (90%) in pregnant and 87 of 114 (76%) in
       nonpregnant women. No significant difference was observed between the
       two groups with regard to the different end points studied, even after
       adjustment for other prognostic variables. Adjusted hazard ratios
       (pregnant/nonpregnant) were 0.92 for death (95% confidence interval [CI]
       0.40-2.12), 1.02 for occurrence of a first AIDS-defining event (95% CI
       0.48-2.18), and 1.20 for drop of the CD4 to less than 200/mm3 (95% CI
       0.63-2.27). CONCLUSION: In a cohort of HIV-infected women with mild to
       moderate immunosuppression, pregnancy did not accelerate progression to
       AIDS or death.
 DE    Adolescence  Adult  Comparative Study  Confidence Intervals  CD4
       Lymphocyte Count  Disease-Free Survival  Female  Follow-Up Studies
       Human  *HIV Seropositivity/IMMUNOLOGY/MORTALITY  Pregnancy  *Pregnancy
       Complications, Infectious/IMMUNOLOGY/MORTALITY  Prognosis  Prospective
       Studies  Support, Non-U.S. Gov't  Survival Rate  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

