       Document 0318
 DOCN  M9630318
 TI    Clinical viral infections and temporal bone histologic studies of
       patients with AIDS.
 DT    9603
 AU    Davis LE; Rarey KE; McLaren LC; Neurology Service, Albuquerque Veterans
       Affairs Medical Center,; NM 87108, USA.
 SO    Otolaryngol Head Neck Surg. 1995 Dec;113(6):695-701. Unique Identifier :
       AIDSLINE MED/96101830
 AB    The brain, eye, and inner ear are each protected from blood-borne
       infectious agents by a barrier that has some anatomic and functional
       differences. In patients with AIDS, opportunistic infections of the
       central nervous system and eye are frequent. Little is known about the
       incidence of middle and inner ear infections in patients with AIDS, but
       deafness and severe vertigo are uncommon. We studied 14 homosexual men
       with AIDS, aged 28 to 55 years, for 1 to 2 years until death. No patient
       had deafness, but one had vertigo. Adenovirus type 6 and cytomegalovirus
       were isolated from the middle ear cavity in four patients. Temporal bone
       histology demonstrated acute otitis media in four, chronic otitis media
       in two, and serous otitis media in three. Adenovirus type 6 and
       cytomegalovirus, either alone or with herpes simplex virus type 1, were
       isolated from inner fluids of three patients. Histologic inner ear
       findings were abnormal in only one patient. Viruses were isolated or
       histologically identified in the brains of four patients and in the eyes
       of five patients. In our patients viral infections were nearly as common
       in the inner ears as in the brain and eye, suggesting that protection
       from the blood-labyrinth barrier was similar to that from the other
       barriers. Because the inner ear viral infections were asymptomatic and
       there was an absence of pathologic damage and inflammation, we suggest
       that some viral inner ear infections in patients with AIDS are
       nonpathogenic and elicit no inflammation or that the viral infections
       occur terminally and elicit no inflammation because of immunosuppression
       from the AIDS.
 DE    Acquired Immunodeficiency Syndrome/*PATHOLOGY/*VIROLOGY  Adenovirus
       Infections, Human/*VIROLOGY  Adult  AIDS-Related Opportunistic
       Infections/*VIROLOGY  Brain/VIROLOGY  Cytomegalovirus
       Infections/*VIROLOGY  Ear, Middle/VIROLOGY  Eye/VIROLOGY  Herpes
       Simplex/*VIROLOGY  Herpesvirus 1, Human/ISOLATION & PURIF
       Homosexuality, Male  Human  Labyrinth/VIROLOGY  Labyrinth
       Diseases/*VIROLOGY  Male  Middle Age  Support, U.S. Gov't, Non-P.H.S.
       Temporal Bone/*PATHOLOGY  Vertigo/ETIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

