       Document 0304
 DOCN  M9630304
 TI    Use of furazolidone for the treatment of microsporidiosis due to
       Enterocytozoon bieneusi in patients with AIDS.
 DT    9603
 AU    Dionisio D; Sterrantino G; Meli M; Trotta M; Milo D; Leoncini F;
       Divisione di Malattie Infettive, Ospedale di Careggi, Firenze.
 SO    Recenti Prog Med. 1995 Oct;86(10):394-7. Unique Identifier : AIDSLINE
       MED/96094187
 AB    The efficacy of furazolidone for treatment of intestinal
       microsporidiosis due to Enterocytozoon bieneusi was studied in three
       patients with AIDS. All patients had chronic diarrhoea and weight loss.
       Mean CD4 cell count was 34.6/mm3. A course of furazolidone (100 mg
       orally four times a day) was given for 20 days. The drug was well
       tolerated and neither side effects nor alterations in the laboratory
       parameters were noted. Diarrhoea ceased within a mean of 12 days of
       starting treatment and clearance of microsporidian shedding in stool was
       observed. In one of the patients, however, symptomatic microsporidiosis
       recurred. Therefore furazolidone seems to have a transient but
       significant effect on intestinal infection due to Enterocytozoon
       bieneusi.
 DE    Acquired Immunodeficiency Syndrome/*COMPLICATIONS  Adult  Animal
       Anti-Infective Agents, Local/ADMINISTRATION & DOSAGE/*THERAPEUTIC  USE
       Case Report  Furazolidone/ADMINISTRATION & DOSAGE/*THERAPEUTIC USE
       Human  Intestinal Diseases, Parasitic/*DRUG THERAPY  Male  Microspora
       Infections/*DRUG THERAPY  *Microsporida  Time Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

