       Document 0299
 DOCN  M9630299
 TI    Inhibitors of HIV nucleocapsid protein zinc fingers as candidates for
       the treatment of AIDS.
 DT    9603
 AU    Rice WG; Supko JG; Malspeis L; Buckheit RW Jr; Clanton D; Bu M; Graham
       L; Schaeffer CA; Turpin JA; Domagala J; et al; Laboratory of Antiviral
       Drug Mechanisms, PRI/DynCorp., National; Cancer Institute-Frederick
       Cancer Research and Development; Center, MD 21702, USA.
 SO    Science. 1995 Nov 17;270(5239):1194-7. Unique Identifier : AIDSLINE
       MED/96072970
 AB    Strategies for the treatment of human immunodeficiency virus-type 1
       (HIV-1) infection must contend with the obstacle of drug resistance.
       HIV-1 nucleocapsid protein zinc fingers are prime antiviral targets
       because they are mutationally intolerant and are required both for acute
       infection and virion assembly. Nontoxic disulfide-substituted benzamides
       were identified that attack the zinc fingers, inactivate cell-free
       virions, inhibit acute and chronic infections, and exhibit broad
       antiretroviral activity. The compounds were highly synergistic with
       other antiviral agents, and resistant mutants have not been detected.
       Zinc finger-reactive compounds may offer an anti-HIV strategy that
       restricts drug-resistance development.
 DE    Amino Acid Sequence  Animal  Antiviral
       Agents/CHEMISTRY/*PHARMACOLOGY/PHARMACOKINETICS
       Benzamides/CHEMISTRY/*PHARMACOLOGY/PHARMACOKINETICS  Biological
       Availability  Capsid/*ANTAGONISTS & INHIB/CHEMISTRY  Cell Line
       Disulfides/CHEMISTRY/*PHARMACOLOGY/PHARMACOKINETICS  Drug Resistance,
       Microbial  Drug Synergism  Gene Products, gag/*ANTAGONISTS &
       INHIB/CHEMISTRY  Human  HIV-1/*DRUG EFFECTS/PHYSIOLOGY  Male  Mice
       Molecular Sequence Data  Support, U.S. Gov't, P.H.S.  Zinc Fingers/*DRUG
       EFFECTS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

