       Document 0268
 DOCN  M9630268
 TI    TCR gamma/delta + and CD8+TCR alpha/beta + intraepithelial lymphocytes
       (IEL) express proliferation marker (Ki-67) in the coeliac lesion.
 DT    9603
 AU    Halstensen TS; Brandtzaeg P; Laboratory for Immunohistochemistry and
       Immunopathology (LIIPAT),; National Hospital, University of Oslo,
       Norway.
 SO    Adv Exp Med Biol. 1995;371B:1333-8. Unique Identifier : AIDSLINE
       MED/96001750
 AB    In conclusion, it appears that gluten induces a non-proliferative
       activation of CD4+ lamina propria T cells, but a proliferative
       activation in the TCR alpha/beta +CD8+ and TCR gamma/delta + IEL
       subsets. Although the increased density of TCR alpha/beta +CD8+ and TCR
       gamma/delta + IEL in the coeliac lesion may be secondary to T cell
       mediated immune activation in the lamina propria, a direct and primary
       antigen-driven proliferation of IEL (perhaps CD1-dependent29) cannot be
       excluded.
 DE    Adolescence  Adult  Aged  Antigens, CD8/METABOLISM  Biological Markers
       Celiac Disease/*IMMUNOLOGY/PATHOLOGY  Cell Division  Child  Child,
       Preschool  CD8-Positive T-Lymphocytes/IMMUNOLOGY/PATHOLOGY  Human
       Immunity, Mucosal  Infant  Intestinal Mucosa/*IMMUNOLOGY/PATHOLOGY
       Jejunum/IMMUNOLOGY/PATHOLOGY  Middle Age  Neoplasm Proteins/*METABOLISM
       Nuclear Proteins/*METABOLISM  Receptors, Antigen, T-Cell,
       alpha-beta/METABOLISM  Receptors, Antigen, T-Cell,
       gamma-delta/METABOLISM  Receptors, Interleukin-2/METABOLISM
       T-Lymphocyte Subsets/*IMMUNOLOGY/PATHOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

