       Document 0265
 DOCN  M9630265
 TI    T cell responses in macaques after vaginal immunization with particulate
       SIV p27 antigen.
 DT    9603
 AU    Panagiotidi C; Bergmeier LA; Gearing AJ; Adams SE; Lehner T; Department
       of Immunology, UMDS, Guy's Hospital, London, United; Kingdom.
 SO    Adv Exp Med Biol. 1995;371B:1575-80. Unique Identifier : AIDSLINE
       MED/96001797
 AB    Rhesus monkeys were immunized by the vaginal and oral routes using a
       recombinant particulate simian immunodeficiency virus (SIV) antigen.
       Augmenting vaginal by oral immunization in macaques elicits
       proliferative CD4+ T cells in the circulation which are specific to the
       immunizing p27 antigen. Reconstitution of enriched CD4+ T cells, B cells
       and macrophages from circulating mononuclear cells help B cells in
       specific IgA anti-p27 antibody synthesis. The results suggest that
       augmented vaginal immunization induces systemic CD4+ T and B cell
       responses which may play a part in the protective immunity against SIV
       (HIV) infection.
 DE    Administration, Intravaginal  Administration, Oral  Animal  Antibodies,
       Viral/BIOSYNTHESIS  Antigens, Viral/*ADMINISTRATION & DOSAGE
       B-Lymphocytes/IMMUNOLOGY  CD4-Positive T-Lymphocytes/IMMUNOLOGY
       CD8-Positive T-Lymphocytes/IMMUNOLOGY  Female  Gene Products,
       gag/*ADMINISTRATION & DOSAGE/*IMMUNOLOGY  Human  HIV
       Infections/IMMUNOLOGY/PREVENTION & CONTROL/TRANSMISSION  Immunity,
       Mucosal  *Immunization  Lymphocyte Transformation  Macaca fascicularis
       Macaca mulatta  SAIDS Vaccines/ADMINISTRATION & DOSAGE  SIV/*IMMUNOLOGY
       T-Lymphocytes/*IMMUNOLOGY  Vagina/*IMMUNOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

