       Document 0256
 DOCN  M9630256
 TI    Detection of hepatitis C virus antibodies and specific hepatitis C virus
       ribonucleic acid sequences in cord bloods from a heterogeneous prenatal
       population.
 DT    9603
 AU    Silverman NS; Snyder M; Hodinka RL; McGillen P; Knee G; Department of
       Obstetrics and Gynecology, Thomas Jefferson; University Hospital,
       Philadelphia, PA, USA.
 SO    Am J Obstet Gynecol. 1995 Nov;173(5):1396-400. Unique Identifier :
       AIDSLINE MED/96081767
 AB    OBJECTIVE: Our aim was to quantify the prevalence of at-risk pregnancies
       for maternal-fetal hepatitis C virus transmission in a heterogeneous
       prenatal population by detection of both hepatitis C virus-specific
       antibody and hepatitis C virus ribonucleic acid sequences in cord bloods
       from their deliveries. STUDY DESIGN: An anonymous serosurvey of 1432
       consecutive umbilical cord blood samples were analyzed for hepatitis C
       virus antibodies with a second-generation enzyme immunoassay with all
       hepatitis C virus antibody-positive samples batched and analyzed for
       both human immunodeficiency virus antibodies and hepatitis C virus
       ribonucleic acid sequences by polymerase chain reaction. RESULTS:
       Forty-seven of the samples (3.2%) were positive for hepatitis C virus
       antibodies; seropositivity rates differed significantly by socioeconomic
       status but not by race. Significantly more of the antibody-positive
       women underwent cesarean section for delivery (31.9% vs 21.9%, p =
       0.03). Three (6.4%) hepatitis C virus antibody-positive samples were
       also human immunodeficiency virus-antibody positive, whereas nine
       (19.1%) were hepatitis C virus ribonucleic acid positive. CONCLUSION: As
       many as 19% of hepatitis C virus antibody-positive women in this study
       also had hepatitis C virus ribonucleic acid isolated from their delivery
       cord blood samples, which may indicate an increased risk of vertical
       hepatitis C virus transmission in those pregnancies. Hepatitis C
       virus-specific antibody and ribonucleic acid detection may also be
       markers for other pregnancy complications that result in higher rates of
       cesarean section for these women.
 DE    Base Sequence  Cesarean Section  Comparative Study  Delivery  Disease
       Transmission, Vertical  DNA Primers  Female  Fetal
       Blood/*IMMUNOLOGY/*VIROLOGY  Hepatitis
       C/DIAGNOSIS/*EPIDEMIOLOGY/TRANSMISSION  Hepatitis C Antibodies/*BLOOD
       Hepatitis C Viruses/IMMUNOLOGY/*ISOLATION & PURIF  Human  Infant,
       Newborn  Molecular Sequence Data  Oligonucleotide Probes
       Philadelphia/EPIDEMIOLOGY  Pregnancy  Pregnancy Complications,
       Infectious/VIROLOGY  RNA, Viral/*BLOOD  Socioeconomic Factors  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

