       Document 0250
 DOCN  M9630250
 TI    Cutaneous presentations of lymphoma in human immunodeficiency virus
       disease. Predominance of T cell lineage.
 DT    9603
 AU    Kerschmann RL; Berger TG; Weiss LM; Herndier BG; Abrahms KM; Heon V;
       Schulze K; Kaplan LD; Resnik SD; LeBoit PE; Department of Pathology,
       University of California Medical Center,; San Francisco, USA.
 SO    Arch Dermatol. 1995 Nov;131(11):1281-8. Unique Identifier : AIDSLINE
       MED/96067815
 AB    BACKGROUND AND DESIGN: Most non-Hodgkin's lymphomas in patients with
       human immunodeficiency virus infection are of B-cell lineage. Cutaneous
       lymphoma in the human immunodeficiency virus disease has not been
       systematically reviewed. We studied 25 patients with both human
       immunodeficiency virus infection and cutaneous presentations of
       lymphoma, using immunohistochemistry and in situ hybridization for
       Epstein-Barr virus. RESULTS: Two groups of patients were discerned: (1)
       those with conditions similar to mycosis fungoides or Sezary syndrome
       with an indolent course (n = 8) and (2) those with nodules or papules,
       greater immunosuppression, a rapid clinical course, and large cell
       lymphoma seen on biopsy specimens (n = 17). The epidermotropic lymphomas
       were T-cell lineage and CD30-. Thirteen of the large cell lymphomas were
       also of the T-cell type, and 71% were CD30+. Epstein-Barr virus was
       absent in the epidermotropic lymphomas, but it was present in 73% of the
       nonepidermotropic cases. CONCLUSIONS: Two forms of human
       immunodeficiency virus-associated cutaneous lymphoma were found:
       indolent disease resembling mycosis fungoides or Sezary syndrome and
       large cell lymphomas with a poor prognosis, whose cells often had a
       CD30+ T-cell phenotype and harbored the Epstein-Barr virus.
 DE    Adult  Human  Immunophenotyping  Lymphoma, AIDS-Related/*PATHOLOGY
       Lymphoma, T-Cell, Cutaneous/*PATHOLOGY  Middle Age  Mycosis
       Fungoides/PATHOLOGY  Sezary Syndrome/PATHOLOGY  Skin
       Neoplasms/*PATHOLOGY  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

