       Document 0248
 DOCN  M9630248
 TI    The diagnostic value of morphometry on blood lymphocytes in
       erythrodermic actinic reticuloid.
 DT    9603
 AU    Preesman AH; Schrooyen SJ; Toonstra J; van der Putte SC; Rademakers LH;
       Willemze R; van Vloten WA; Department of Dermatology, University
       Hospital Utrecht, The; Netherlands.
 SO    Arch Dermatol. 1995 Nov;131(11):1298-303. Unique Identifier : AIDSLINE
       MED/96067817
 AB    BACKGROUND: As the differential diagnosis of erythrodermic actinic
       reticuloid vs Sezary syndrome (SS) can be very difficult, we examined
       the value of the nuclear contour index (NCI) on blood lymphocytes as the
       criterion for differential diagnoses. The NCI is defined as the nuclear
       parameter divided by the square root of the nuclear area. Three
       different parameters were studied: mean NCI, percentage of cells with an
       NCI of 6.5 or greater, and the highest NCI. These indexes were studied
       on blood lymphocyte samples obtained from 10 patients with erythrodermic
       actinic reticuloid and were compared with the findings in 10 patients
       with other benign forms of erythroderma and in seven patients suffering
       from SS. RESULTS: The patients with erythrodermic actinic reticuloid
       differed significantly from the group with SS regarding the percentage
       of cells with an NCI of 6.5 or greater and the highest NCI, but not when
       the mean NCI was considered. All three parameters revealed
       nonsignificant results for erythrodermic actinic reticuloid compared
       with other benign forms of erythroderma. The group with SS differed
       significantly from the patients with other benign forms of erythroderma
       regarding all three parameters. By combining three morphometric criteria
       (mean NCI, > or = 5.5; > 30% lymphoid cells with an NCI of > or = 6.5;
       and highest NCI, > or = 11.5), all patients with erythrodermic actinic
       reticuloid or other benign forms of erythroderma and six of the seven
       patients with SS were correctly classified. CONCLUSION: Our data
       indicate that assessment of the NCI on peripheral blood lymphocytes is
       of value in the differential diagnosis of erythrodermic actinic
       reticuloid vs SS.
 DE    Aged  Aged, 80 and over  Cell Nucleus/*PATHOLOGY  Comparative Study
       CD4-CD8 Ratio  Dermatitis, Exfoliative/BLOOD/DIAGNOSIS  Diagnosis,
       Differential  Female  Follow-Up Studies  Human  Lymphocytes/*PATHOLOGY
       Male  Middle Age  Photosensitivity Disorders/*BLOOD/*DIAGNOSIS  Sezary
       Syndrome/BLOOD/DIAGNOSIS  Skin Neoplasms/BLOOD/DIAGNOSIS  CLINICAL TRIAL
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

