       Document 0242
 DOCN  M9630242
 TI    Host cell antigenic profile acquired by HIV-1 is a marker of its
       cellular origin.
 DT    9603
 AU    Abbate I; Capobianchi MR; Fais S; Castilletti C; Mercuri F; Cordiali Fei
       P; Ameglio F; Dianzani F; Institute of Virology, University La Sapienza,
       Rome, Italy.
 SO    Arch Virol. 1995;140(10):1849-54. Unique Identifier : AIDSLINE
       MED/96105342
 AB    HIV-1 acquires cell membrane proteins during budding. The cell membrane
       proteins (CMP) profile of laboratory HIV-1 strains grown in different
       host cells was established, by using an immobilized antibody capture
       (IAC), to verify whether CMPs present on HIV-1 correlate with its host
       cell origin. HIV-1 grown in different cell lines incorporates cell
       markers such as CD3, CD19, CD14, CD31 and IL 2-R, according to the
       distinctive expression of these antigens on the host cells. Furthermore,
       also T-tropic and monocytotropic HIV-1 strains display host cell
       specific markers, supporting the hypothesis that virus associated CMPs
       are a marker of host cell origin.
 DE    Antigens, CD/METABOLISM  Cell Line  Cell Membrane/IMMUNOLOGY  Human  HIV
       Antigens/*METABOLISM  HIV-1/GROWTH & DEVELOPMENT/*IMMUNOLOGY  Membrane
       Proteins/*METABOLISM  Support, Non-U.S. Gov't  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

