       Document 0241
 DOCN  M9630241
 TI    BK virus and a new type of JC virus excreted by HIV-1 positive patients
       in rural Tanzania.
 DT    9603
 AU    Agostini HT; Brubaker GR; Shao J; Levin A; Ryschkewitsch CF; Blattner
       WA; Stoner GL; Laboratory of Experimental Neuropathology, National
       Institute of; Neurological Disorders and Stroke, NIH, Bethesda,
       Maryland, USA.
 SO    Arch Virol. 1995;140(11):1919-34. Unique Identifier : AIDSLINE
       GENBANK/U21844
 AB    HIV-1 positive patients from Tanzanian villages near Shirati were
       examined for urinary excretion of the human polyomaviruses JC and BK
       using the polymerase chain reaction (PCR). BK virus (BKV) was detected
       in 11 of 23 individuals tested. The BKV DNA sequences were all closely
       related to prototype Gardner strain and BKV (DUN). In contrast, a new
       type of JCV, termed Type 3 [or JCV (Shi)], was identified in seven of
       these same 23 individuals by comparison with Type 1 and Type 2 sequences
       of the VP1/intergenic/T antigen region of U.S., European and Asian
       strains. This suggests that JCV and BKV, although closely related, have
       different evolutionary histories within the African population. The six
       BKV regulatory regions amplified all showed the archetypal
       configuration. However, two of the seven JCV regulatory regions showed
       rearrangements: a small deletion and an inverted repeat. JCV causes a
       fatal demyelinating disease, progressive multifocal leukoencephalopathy
       (PML), in about 5% of AIDS patients in Europe and the U.S.A., but only
       one case has been reported in Africa. Our results suggest that this
       rarity of PML is not due to the absence of JCV in the African
       population.
 DE    Adolescence  Adult  Amino Acid Sequence  Base Sequence  Capsid/GENETICS
       DNA Primers/CHEMISTRY  DNA, Viral/URINE  Female  Human  HIV
       Infections/COMPLICATIONS/*MICROBIOLOGY  Male  Middle Age  Molecular
       Sequence Data  Papovaviridae Infections/*COMPLICATIONS  Polyomavirus
       hominis 1/*GROWTH & DEVELOPMENT/GENETICS  Polyomavirus hominis
       2/CLASSIFICATION/*GROWTH & DEVELOPMENT/  GENETICS  Regulatory Sequences,
       Nucleic Acid  Support, Non-U.S. Gov't  Support, U.S. Gov't, P.H.S.
       Tanzania  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

