       Document 0235
 DOCN  M9630235
 TI    Herpes zoster, immunological deterioration and disease progression in
       HIV-1 infection.
 DT    9603
 AU    Veenstra J; Krol A; van Praag RM; Frissen PH; Schellekens PT; Lange JM;
       Coutinho RA; van der Meer JT; Department of Public Health and
       Environment, University of; Amsterdam, The Netherlands.
 SO    AIDS. 1995 Oct;9(10):1153-8. Unique Identifier : AIDSLINE MED/96098131
 AB    OBJECTIVE: To study the incidence of herpes zoster, the relationship
       between herpes zoster and immunological markers, and the prognostic
       value of herpes zoster for progression of HIV disease. DESIGN AND
       METHODS: A total of 966 homosexual participants in The Amsterdam Cohort
       Study were studied. Herpes zoster was defined by its characteristic
       clinical presentation. Incidence was calculated using Poisson
       regression, cumulative incidence by the Kaplan-Meier product-limit
       method and the prognostic value was evaluated using Cox proportional
       hazards model. RESULTS: The incidence of first episodes of herpes zoster
       was 3.31 per 1000 person-years (PY) in HIV-seronegatives and 51.51 per
       1000 PY in HIV-1-seropositive individuals. Recurrences only occurred in
       HIV-1-positive patients (25.6%). Cumulative incidences of first episodes
       increased linearly with the duration of follow-up. In
       HIV-1-seropositives the incidence was 31.2 per 1000 PY at CD4+ cells >
       or = 500 x 10(6)/l, 47.2 per 1000 PY [relative risk (RR), 1.51; 95%
       confidence interval (CI), 0.78-2.94] at CD4+ cells 200-499 x 10(6)/l and
       97.5 per 1000 PY (RR, 3.13; 95% CI, 1.54-6.32) at CD4+ cells < 200 x
       10(6)/l. Besides CD4+ cell counts, CD3 monoclonal antibodies and
       phytohaemagglutinin-induced T-cell reactivity were independent
       predictors for herpes zoster. The hazard ratio for AIDS after herpes
       zoster was 1.6 (95% CI, 1.1-2.4) and for death 1.7 (95% CI, 1.1-2.5),
       but these were not independent from CD4+ cell counts. CONCLUSION: In
       HIV-1 infection the incidence of herpes zoster increases with the
       decrease of CD4+ cell counts and T-cell reactivity, but herpes zoster is
       not an independent predictor for disease progression.
 DE    Adult  Aged  Antibodies, Monoclonal  Biological Markers  CD4 Lymphocyte
       Count  Disease Progression  Herpes
       Zoster/COMPLICATIONS/*EPIDEMIOLOGY/*IMMUNOLOGY  Homosexuality, Male
       Human  HIV Seronegativity/IMMUNOLOGY  HIV
       Seropositivity/*COMPLICATIONS/IMMUNOLOGY  *HIV-1  Incidence  Male
       Middle Age  Prognosis  Prospective Studies  Recurrence  Regression
       Analysis  Support, Non-U.S. Gov't  T-Lymphocytes/IMMUNOLOGY  JOURNAL
       ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

