       Document 0217
 DOCN  M9630217
 TI    [Characteristics of chronic delta hepatitis in patients wih HIV
       infection]
 DT    9603
 AU    De Pouplana M; Soriano V; Garcia-Samaniego J; Enriquez A; Munoz F;
       Gonzalez-Lahoz J; Servicio de Enfermedades Infecciosas. Centro de
       Investigaciones; Clinicas. Instituto de Salud Carlos III, Madrid.
 SO    Rev Esp Enferm Dig. 1995 Oct;87(10):721-4. Unique Identifier : AIDSLINE
       MED/96103278
 AB    BACKGROUND: Hepatitis Delta virus (HDV) induces severe liver disease in
       HBsAg carriers. In regions such as Spain, drug addicts make-up a large
       part of the HIV-positive population and they are at risk of HDV
       infection. Natural history of chronic hepatitis D is not well known in
       HIV-infected patients. METHODS: We reviewed the clinical charts of 37
       patients attending our institution from 1989 to 1993, fulfilling the
       criteria for chronic hepatitis D. We compared all clinical,
       epidemiological, serological and histological findings between both
       HIV-positive and HIV-negative patients. RESULTS: All the following
       parameters showed significant statistical differences between the both
       groups: mean ALT levels (175 vs 79 respectively, p < 0.05), previous
       episodes of hepatic decompensation (37% vs 10%, p < 0.01), the
       circulating Delta antigen (26% vs 10%, p < 0.05), the presence of HBeAg
       in serum (41% vs 0%, p < 0.01) and the HCV coinfection (85% vs 20%, p <
       0.01). Histological findings were not significantly different comparing
       both groups, as chronic active hepatitis with cirrhosis was the most
       common diagnosis. CONCLUSION: Chronic hepatitis D may present a more
       severe course in HIV-infected patients. The higher replication of HDV
       and the presence of HCV coinfection could explain this worst outcome.
 DE    Adult  Chronic Disease  Comparative Study  Delta
       Infection/DIAGNOSIS/*ETIOLOGY  English Abstract  Female  Hepatitis
       C/COMPLICATIONS  Human  HIV Infections/*COMPLICATIONS  HIV
       Seronegativity  HIV Seropositivity/COMPLICATIONS  Male  Middle Age  Risk
       Factors  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

