       Document 0215
 DOCN  M9630215
 TI    Sjogren's syndrome.
 DT    9603
 AU    Fox RI; Department of Rheumatology, Scripps Clinic and Research;
       Foundation, La Jolla, CA 92037, USA.
 SO    Curr Opin Rheumatol. 1995 Sep;7(5):409-16. Unique Identifier : AIDSLINE
       MED/96089426
 AB    The literature published over the past year on Sjogren's syndrome is
       reviewed, including epidemiology, genetic, environmental, and clinical
       features. The criteria for the classification of Sjogren's syndrome
       remain controversial, potentially leading to confusion in clinical
       practice and in research publications. Dryness of the eyes and mouth can
       result from either interruption of the neurovascular innervation of the
       glands or from any infiltrative process that affects the ability of the
       glands to secrete. Recent studies have demonstrated that sicca symptoms
       also can result from autonomic neuropathy in patients with diabetes,
       multiple sclerosis, or systemic lupus erythematosus. It is suggested
       that the term Sjogren's syndrome be used to describe one subset of
       patients with sicca symptoms who exhibit particular major
       histocompatibility complex antigens, the presence of T cell lymphoid
       infiltrates on glandular biopsy, and specific autoantibodies in their
       sera. Even using these restrictive criteria for classification, no
       single environmental factor has been shown as necessary or sufficient
       for pathogenesis. Recent studies on Epstein-Barr virus have indicated a
       novel deleted virus in some Chinese Sjogren's syndrome patients. Other
       patients with sicca symptoms and autoimmune features may have infections
       with HIV or hepatitis C virus.
 DE    Animal  Disease Models, Animal  Environment  Human  Major
       Histocompatibility Complex/GENETICS  Sjogren's
       Syndrome/*COMPLICATIONS/*ETIOLOGY/THERAPY  JOURNAL ARTICLE  REVIEW
       REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

