       Document 0196
 DOCN  M9630196
 TI    Gonococcal serovar patterns in Glasgow: 1990-1992.
 DT    9603
 AU    Ross JD; Weir M; Horn CK; Moyes A; Young H; Department of Genitourinary
       Medicine, Edinburgh Royal Infirmary,; Scotland, UK.
 SO    Br J Biomed Sci. 1995 Jun;52(2):87-92. Unique Identifier : AIDSLINE
       MED/96086115
 AB    Using monoclonal antibodies directed against protein 1 (major outer
       membrane protein) in the cell wall of Neisseria gonorrhoeae it is
       possible to serotype the gonococcus into different sub-groups. This
       study was designed to analyse the distribution of such serovars in
       Glasgow, Scotland, and report associations between serovars and clinical
       features of infection. N. gonorrhoeae isolated from all patients with a
       diagnosis of gonorrhoea attending genitourinary medicine clinics in
       Glasgow were serotyped between January 1990 and December 1992. The
       results were then correlated with sexual orientation of patients,
       penicillin sensitivity, site of infection, location of acquisition of
       infection and presence of symptoms. Six hundred and four episodes of
       gonococcal infection were analysed and an association between certain
       serovars with sexual orientation, penicillin sensitivity and
       asymptomatic infection was found. No association between serovar type
       and locality of acquisition of infection was apparent. Although there
       was a decreasing trend in the incidence of gonorrhoea overall,
       infections in homosexual men increased over the three-year study period.
       The associations between serovars and other features of gonococcal
       infection are discussed. The observed increase in homosexually-acquired
       infection has implications with regard to the spread of human
       immunodeficiency virus infection in this area, and suggests that
       attempts to promote safer sex in this group are failing.
 DE    Adolescence  Adult  Drug Resistance, Microbial  Female
       Gonorrhea/*EPIDEMIOLOGY  Human  Male  Neisseria
       gonorrhoeae/*CLASSIFICATION  Penicillins/PHARMACOLOGY  Prevalence
       Prospective Studies  Scotland/EPIDEMIOLOGY  Serotyping  Sex Behavior
       Urethral Diseases/MICROBIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

