       Document 0189
 DOCN  M9630189
 TI    [Phenotype of lymphocytes in bronchoalveolar lavage fluid of patients
       with lung fibrosis in the course of scleroderma]
 DT    9603
 AU    Domagala-Kulawik J; Hoser G; Doboszynska A; Kawiak J; Droszcz W; Kliniki
       Pneumonologii AM w Warszawie.
 SO    Pneumonol Alergol Pol. 1995;63(7-8):382-8. Unique Identifier : AIDSLINE
       MED/96106086
 AB    Patients with systemic sclerosis frequently develop interstitial lung
       disease. One of the major sites of pathogenic activity are lymphocytes
       from lung interstitium. The purpose of this work was phenotype analysis
       of lymphocytes in bronchoalveolar lavage fluid (BALF) with flow
       cytofluorometry. We found an increase number of CD8+ lymphocytes and
       CD8+/T ratio, and an reduced CD4+/CD8+ ratio in patients when compared
       to healthy volunteers. The diffusing capacity (DLCO) correlated positive
       with percentage of neutrophils and HLA-DR+ lymphocytes. There are the
       features of mixed type alveolitis in patients with short disease
       duration. We found increase number of lymphocytes, neutrophils, CD8+
       lymphocytes, HLA-DR+ lymphocytes and CD25+ lymphocytes in this patients.
       We concluded that fluorocytometric BALF analysis may be useful for the
       diagnosis and management of lung involvement in patients with
       scleroderma before the treatment.
 DE    Adult  Aged  Antigens, Differentiation/ANALYSIS  Bronchoalveolar Lavage
       Fluid/*CYTOLOGY/IMMUNOLOGY  CD4 Lymphocyte Count  English Abstract
       Female  Fluoroimmunoassay  Human  HLA-DR Antigens/ANALYSIS
       Immunophenotyping  Male  Middle Age  Pulmonary
       Fibrosis/DIAGNOSIS/*IMMUNOLOGY  Scleroderma, Systemic/*IMMUNOLOGY
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

