       Document 0188
 DOCN  M9630188
 TI    Analysis of genetic diversity at the arom locus in isolates of
       Pneumocystis carinii.
 DT    9603
 AU    Banerji S; Lugli EB; Miller RF; Wakefield AE; Department of Paediatrics,
       John Radcliffe Hospital, United; Kingdom.
 SO    J Eukaryot Microbiol. 1995 Nov-Dec;42(6):675-9. Unique Identifier :
       AIDSLINE MED/96081462
 AB    The DNA sequences of a portion of the 5-enolpyruvyl shikimate phosphate
       synthase domain of the arom gene, encoding the pentafunctional AROM
       protein, were determined from isolates of Pneumocystis carinii from five
       mammalian host species (rat, human, ferret, rabbit and mouse). High
       levels of genetic divergence were found among P. carinii derived from
       different host species, 7-22% at the DNA sequence level, and 7-26% at
       the derived amino acid sequence level. Two separate and distinct
       sequences were isolated from infected ferret lungs. Low levels of
       divergence were seen in human-derived organisms.
 DE    Amino Acid Sequence  Animal  AIDS-Related Opportunistic
       Infections/MICROBIOLOGY  Base Sequence  Bronchoalveolar Lavage
       Fluid/MICROBIOLOGY  Comparative Study  DNA Primers  Ferrets  *Genes,
       Fungal  Human  Mice  Mice, Inbred BALB C  Molecular Sequence Data
       Pneumocystis carinii/ENZYMOLOGY/*GENETICS/*ISOLATION & PURIF  Pneumonia,
       Pneumocystis carinii/COMPLICATIONS/*MICROBIOLOGY  Polymerase Chain
       Reaction  Rabbits  Rats  Rats, Sprague-Dawley  Sequence Homology, Amino
       Acid  Sequence Homology, Nucleic Acid  Species Specificity  Support,
       Non-U.S. Gov't  Transferases/BIOSYNTHESIS/*GENETICS  *Variation
       (Genetics)  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

