       Document 0184
 DOCN  M9630184
 TI    Presence of CD4+ and CD8+ T cells and expression of MHC class I and MHC
       class II antigen in horses with Borna disease virus-induced
       encephalitis.
 DT    9603
 AU    Bilzer T; Planz O; Lipkin WI; Stitz L; Institut fur Neuropathologie,
       Heinrich-Heine-Universitat,; Dusseldorf, Germany.
 SO    Brain Pathol. 1995 Jul;5(3):223-30. Unique Identifier : AIDSLINE
       MED/96048152
 AB    Tissues from 9 horses and 1 donkey suffering from natural Borna disease
       were investigated immunomorphologically. Lymphocytic inflammatory
       reactions and increased expressions of MHC class I and class II antigen
       were found in the brain as well as in the trigeminal and olfactory
       system. Perivascular inflammatory infiltrates were dominated by CD4+ T
       cells, whereas the majority of CD8+ T cells were disseminated
       intraparenchymally. No evidence of inflammation was found in the retina.
       Borna disease virus proteins and nucleic acids were present in the
       hippocampus, thalamus and medulla oblongata in all 10 animals, in the
       cerebral cortex, retina, trigeminal ganglion and nerve in 9, in the
       olfactory epithelium in 6 and in roots and proximal parts of large
       peripheral nerves in 3. No evidence of infection was found in the
       autonomic nervous system, lung, heart, liver, kidney or gut. BDV-
       proteins and nucleic acids were even more abundant in the trigeminal
       system than in the olfactory system, suggesting that infection may have
       occurred via the trigeminal nerve.
 DE    Animal  Borna Disease/IMMUNOLOGY/*VIROLOGY  Brain/IMMUNOLOGY
       CD4-Positive T-Lymphocytes/*IMMUNOLOGY  CD8-Positive
       T-Lymphocytes/*IMMUNOLOGY  Equidae/*IMMUNOLOGY  Histocompatibility
       Antigens/*BLOOD  Histocompatibility Antigens Class I/BLOOD
       Histocompatibility Antigens Class II/BLOOD  Horse Diseases/*IMMUNOLOGY
       Horses  Inflammation/IMMUNOLOGY  Support, Non-U.S. Gov't  Support, U.S.
       Gov't, P.H.S.  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

