       Document 0180
 DOCN  M9630180
 TI    Immune escape and tropism of HIV.
 DT    9603
 AU    McKnight A; Clapham PR; Virology Laboratory, Chester Beatty
       Laboratories, Institute of; Cancer Research, London, UK.
 SO    Trends Microbiol. 1995 Sep;3(9):356-61. Unique Identifier : AIDSLINE
       MED/96093377
 AB    HIV-1 cell tropisms are partly determined by the hypervariable loops
       V1/V2 and V3 in gp120, which also contain epitopes for neutralizing
       antibodies. Mutations conferring tropism changes can result in escape
       from neutralization and vice versa. We examine whether variant viruses
       that can colonize new cell types and simultaneously escape neutralizing
       antibodies have an enhanced advantage in vivo.
 DE    Amino Acid Sequence  Antibodies, Monoclonal/METABOLISM  Human  HIV
       Envelope Protein gp120/*CHEMISTRY/METABOLISM  HIV
       Infections/IMMUNOLOGY/*VIROLOGY  HIV-1/GENETICS/*PHYSIOLOGY  Immunity,
       Cellular/*IMMUNOLOGY  Immunity, Natural/GENETICS  Immunoglobulin
       Variable Region/METABOLISM  Molecular Sequence Data  Mutation
       Neutralization Tests  Tropism/GENETICS/*PHYSIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

