       Document 0178
 DOCN  M9630178
 TI    [Effect of the liposolubility of free radical scavengers on the
       production of antigen P24 from a HIV infected monocytic cell line]
 DT    9603
 AU    Edeas M; Khalfoun Y; Lazizi Y; Vergnes L; Labidalle S; Postaire E;
       Lindenbaum A; Laboratoire de Biochimie, Hopital Antoine-Beclere,
       CLAMART.
 SO    C R Seances Soc Biol Fil. 1995;189(3):367-73. Unique Identifier :
       AIDSLINE MED/96098959
 AB    A large body of evidence indicates that AIDS may be the consequence of a
       virus-induced antioxidant deficiency and implicates reactive oxygen
       species (ROS) in the pathogenesis of HIV infection. The high level of
       antigenic acid and cytokines activities in AIDS results in the
       production of superoxides (O2-), hydrogen peroxide (H202) and hydroxyl
       radicals (OH). HIV-infected T cells display low levels of SOD, catalase,
       thioredoxin and glutatione peroxidase rendering them susceptible to
       undergo apoptosis. Induction of NF kappa B and HIV replication are at
       least in part dependent on reactive oxygen intermediates. We examined
       the protective effects of two antioxidants. Ferulic Acid (FA) and Ethyl
       Ferulate (EF) at 1, 5, 10, 10 microM on the TNF induced HIV activation
       in the chronically infected promonocytic U1 cell line. FA and EF at 5
       microM elicit a marked decrease of HIV p24 release. HIV inhibition was
       greater after pretreatment with EF than with FA. At these
       concentrations, no cytotoxicity was observed. When SOD (100 UI) was
       combined with EF and FA no more inhibition was observed. But when SOD
       was added alone, it induced a marked inhibition (30%). This class of
       drugs may present potential interest as antiviral agents or as adjuvant
       therapy in AIDS.
 DE    Antioxidants/*PHARMACOLOGY  Coumaric Acids/*PHARMACOLOGY  Drug Synergism
       English Abstract  Free Radical Scavengers/*PHARMACOLOGY  Human  HIV
       Antigens/*DRUG EFFECTS  HIV Core Protein p24/IMMUNOLOGY  HIV
       Infections/*IMMUNOLOGY  Lipids/METABOLISM
       Monocytes/*IMMUNOLOGY/*VIROLOGY  Solubility  Superoxide
       Dismutase/PHARMACOLOGY  Support, Non-U.S. Gov't  Virus Replication/DRUG
       EFFECTS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

