       Document 0176
 DOCN  M9630176
 TI    Lymphomas of the oral soft tissues are not preferentially associated
       with latent or replicative Epstein-Barr virus.
 DT    9603
 AU    Gulley ML; Sargeant KP; Grider DJ; Eagan PA; Davey DD; Damm DD; Robinson
       RA; Vandersteen DP; McGuff HS; Banks PM; University of Texas Health
       Science Center at San Antonio, USA.
 SO    Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 1995 Oct;80(4):425-31.
       Unique Identifier : AIDSLINE MED/96123984
 AB    OBJECTIVES. Epstein-Barr virus is periodically shed in the saliva of
       persons infected by the virus. Epstein-Barr virus has been implicated in
       the pathogenesis of certain subtypes of lymphoma, particularly
       high-grade lymphomas. Because high-grade subtypes represent the majority
       of lymphomas that arise in oral soft tissues, we hypothesized that
       Epstein-Barr virus might be preferentially associated with oral
       lymphomas. STUDY DESIGN. A series of 34 oral lymphomas were diagnosed
       according to the revised European-American classification scheme. They
       were examined for the presence of latent Epstein-Barr virus by EBER1 in
       situ hybridization and for expression of the Epstein-Barr virus
       replicative protein, BZLF1, by immunohistochemistry. RESULTS.
       Epstein-Barr virus EBER1 transcripts were detected in 11 of 31 oral
       lymphomas including 7 of 10 AIDS-related lymphomas and only 4 of 21
       lymphomas that occurred in nonimmunocompromised persons. The
       Epstein-Barr virus-containing lymphomas were all high-grade histologic
       subtypes, that is, diffuse large cell, immunoblastic, or Burkitt's
       lymphomas. In contrast, Epstein-Barr virus was not detected in any of
       five low-grade oral lymphomas. In the single case of T-cell lymphoma in
       this study, EBER1 was expressed in the tumor cells. A switch from viral
       latency to replication, as measured by EBV BZLF1 expression, was
       identified in rare lymphoma cells in only four cases. This rate of viral
       replication was not higher than what has been reported in lymphomas
       arising at other anatomic sites. Although one of our lymphomas arose at
       a site of previous oral hairy leukoplakia, there was no other evidence
       that Epstein-Barr virus replication predisposed to development or
       persistence of oral lymphomas. CONCLUSIONS. These data suggest that even
       though Epstein-Barr virus is frequently found in oral secretions,
       neither latent nor replicative Epstein-Barr virus is present more
       commonly in oral lymphomas than in lymphomas arising in other anatomic
       sites, when controlling for immunodeficiency status.
 DE    Adolescence  Adult  Aged  Aged, 80 and over  Burkitt's Lymphoma/VIROLOGY
       Child  DNA-Binding Proteins/ANALYSIS  Female  Herpesvirus 4,
       Human/ISOLATION & PURIF/*PATHOGENICITY  Human  Immunohistochemistry  In
       Situ Hybridization  Lymphoma, AIDS-Related/VIROLOGY  Lymphoma,
       B-Cell/CLASSIFICATION/PATHOLOGY/*VIROLOGY  Lymphoma, Large-Cell,
       Diffuse/VIROLOGY  Lymphoma, Large-Cell, Immunoblastic/VIROLOGY
       Lymphoma, Non-Hodgkin's/CLASSIFICATION/PATHOLOGY/*VIROLOGY  Male  Middle
       Age  Mouth Neoplasms/CLASSIFICATION/PATHOLOGY/*VIROLOGY  RNA,
       Viral/ANALYSIS  Support, U.S. Gov't, Non-P.H.S.  Support, U.S. Gov't,
       P.H.S.  Trans-Activators/ANALYSIS  Viral Proteins/ANALYSIS  Virus
       Activation  Virus Latency  Virus Replication  JOURNAL ARTICLE
       MULTICENTER STUDY

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

