       Document 0169
 DOCN  M9630169
 TI    Fatty acids and plasma antioxidants in HIV-positive patients:
       correlation with nutritional and immunological status.
 DT    9603
 AU    Constans J; Peuchant E; Pellegrin JL; Sergeant C; Hamon C; Dubourg L;
       Thomas MJ; Simonoff M; Pellegrin I; Brossard G; et al; Service de
       Medecine Interne et Pathologie Vasculaire, Hopital; Saint-Andre,
       Bordeaux, France.
 SO    Clin Biochem. 1995 Aug;28(4):421-6. Unique Identifier : AIDSLINE
       MED/96129102
 AB    OBJECTIVE: To investigate red blood cell (RBC) and plasma fatty acids
       (FA) in HIV-positive patients in relation to oxidative stress and
       nutritional or immunological status. DESIGN AND METHODS: FA, plasma
       selenium, vitamins A and E were measured in 95 patients divided into
       four groups according to CD4 cells. RESULTS: Poly- and di-unsaturated FA
       (PUFA, DUFA) decreased and saturated FA (SFA) increased in RBC in the
       patients below 400/mm3 and in plasma in the patients below 50/mm3. RBC
       SFA correlated to CD4 cells, PUFA to MDA. Unlike vitamin E, plasma
       vitamin A and selenium decreased in most groups. Plasma SFA and MUFA
       correlated negatively to selenium and PUFA and DUFA to vitamin E. No
       correlation was found between PUFA and nutritional markers. CONCLUSION:
       FA seem to be modified during HIV infection by oxidative stress and
       disease evolution, but not by denutrition.
 DE    Adult  Antigens, CD4/ANALYSIS  Antigens, CD8/ANALYSIS
       Antioxidants/*ANALYSIS  Case-Control Studies  Erythrocyte
       Membrane/CHEMISTRY  Fatty Acids/*BLOOD  Female  Human  HIV
       Seropositivity/BLOOD/*IMMUNOLOGY  *Immunocompetence  Male
       Malondialdehyde/ANALYSIS  Middle Age  *Nutritional Status  Oxidative
       Stress  Selenium/BLOOD  Vitamin A/BLOOD  Vitamin E/BLOOD  CLINICAL TRIAL
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

