       Document 0168
 DOCN  M9630168
 TI    Opportunistic infections of the central nervous system in children with
       HIV infection: report of 9 autopsy cases and review of literature.
 DT    9603
 AU    Wrzolek MA; Brudkowska J; Kozlowski PB; Rao C; Anzil AP; Klein EA; Del
       Rosario C; Abdu A; Kaufman L; Chandler FW; Department of Pathology,
       State University of New York Health; Science Center, Brooklyn 11203,
       USA.
 SO    Clin Neuropathol. 1995 Jul-Aug;14(4):187-96. Unique Identifier :
       AIDSLINE MED/96123602
 AB    Central nervous system (CNS) abnormalities attributed to direct effects
       of HIV infection are seen in most of children with acquired
       immunodeficiency syndrome (AIDS). Secondary CNS infections with
       opportunistic and common pathogens are infrequent in this age group. We
       report 9 cases of opportunistic infection of the CNS found among 65
       autopsy cases of pediatric AIDS. These included 4 cases of
       cytomegalovirus (CMV) infection, 1 of which was associated with
       aspergillosis, and 2 cases of candidiasis, 1 of which coexisted with
       Mycobacterium avium intracellulare (MAI) infection. There were also 2
       cases of leptomeningitis, 1 due to Mycobacterium tuberculosis (MTB) and
       the other to Cryptococcus neoformans. In 1 child progressive multifocal
       leukoencephalopathy (PML) coexisted with mycotic encephalitis caused by
       an Aspergillus sp.
 DE    Aspergillosis/PATHOLOGY  Aspergillus flavus  Autopsy  AIDS-Related
       Opportunistic Infections/*PATHOLOGY  Candidiasis/PATHOLOGY  Case Report
       Central Nervous System Diseases/*PATHOLOGY  Child  Child, Preschool
       Cytomegalovirus Infections/PATHOLOGY  Female  Human  Infant
       Leukoencephalopathy, Progressive Multifocal/PATHOLOGY  Male
       Mycobacterium avium-intracellulare Infection/PATHOLOGY  Support, U.S.
       Gov't, P.H.S.  JOURNAL ARTICLE  REVIEW  REVIEW OF REPORTED CASES

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

