       Document 0150
 DOCN  M9630150
 TI    CD4 lymphocytes in women with invasive and preinvasive cervical
       neoplasia.
 DT    9603
 AU    Gemignani M; Maiman M; Fruchter RG; Arrastia CD; Gibbon D; Ellison T;
       Department of Obstetrics and Gynecology, State University of New; York,
       Health Science Center at Brooklyn 11203, USA.
 SO    Gynecol Oncol. 1995 Dec;59(3):364-9. Unique Identifier : AIDSLINE
       MED/96095751
 AB    OBJECTIVE. To assess the relationship between CD4 lymphocyte population
       and stage of disease in cervical neoplasia. METHODS. Study population
       was 107 women with invasive cervical cancer, 116 women with cervical
       intraepithelial neoplasia (CIN), and 32 women without neoplasia
       diagnosed in 1988-1994. All women under age 50 were seronegative for the
       human immunodeficiency virus (HIV). All women over age 50 with CD4:CD8
       ratio below normal were HIV-negative. Stage was defined by FIGO criteria
       using clinical findings. CD4 and CD8 lymphocyte populations were
       enumerated by flow cytometry prior to treatment. The normal range of CD4
       counts was defined as 537-1571 cells/mm3. RESULTS. Distribution of CD4
       count was similar in stages I (n = 40), II (n = 24), and III (n = 32),
       with 31% below normal and 9% above normal (mean CD4 count = 881).
       However, in stage IV (n = 11), 64% were below normal and 18% above
       normal (mean CD4 = 591). The difference in distribution between stages
       I-III and stage IV was statistically significant. Among 116 CIN
       patients, 10% had CD4 counts below normal and 3% above normal (mean CD4
       = 910). Among 32 women without cervical neoplasia, 0% had CD4 counts
       below normal and 3% above normal. The difference between CIN and
       invasive cancer in the distribution of CD4 counts and CD8 counts was
       significant (P < 0.01). There was no difference in the CD4 count
       distribution by CIN severity. Forty-five percent of patients with
       below-normal CD4 counts at diagnosis developed recurrent cancer compared
       to 43% of patients with normal or above-normal CD4 counts. CONCLUSION.
       Women with invasive cervical cancer have lower CD4 counts and a broader
       distribution compared to women with preinvasive or no neoplasia.
       Metastatic cancer at diagnosis was associated with severely depressed
       CD4 count.
 DE    Cervical Intraepithelial Neoplasia/IMMUNOLOGY/PATHOLOGY  Cervix
       Neoplasms/IMMUNOLOGY/*PATHOLOGY  Cohort Studies  CD4-CD8 Ratio
       CD4-Positive T-Lymphocytes/*PATHOLOGY  CD8-Positive
       T-Lymphocytes/PATHOLOGY  Female  Human  Middle Age  Neoplasm
       Invasiveness  Neoplasm Staging  Reference Values  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

