       Document 0148
 DOCN  M9630148
 TI    Levels of the circulating cell adhesion molecule E-selectin and disease
       progression in HIV infection.
 DT    9603
 AU    Sfikakis PP; Tzavara V; Sipsas N; Kosmopoulou O; Sfikakis P; Kordossis
       T; First Dept. of Propedeutic Medicine, Athens University Medical;
       School, Laikon General Hospital, Greece.
 SO    Infection. 1995 Jul-Aug;23(4):207-11. Unique Identifier : AIDSLINE
       MED/96055298
 AB    The levels of soluble form of E-Selectin (sEs), or endothelial-leukocyte
       adhesion molecule-1, were measured in 96 sera derived from 72
       HIV-infected patients at different stages of the disease, 60 healthy
       blood donors, and 50 HIV-negative patients with infections, using a
       quantitative ELISA. Levels of sEs in HIV-infected individuals without
       AIDS, according to the 1993 classification system of the Centers for
       Disease Control, were higher than normal (mean +/- SEM 48 +/- 4 versus
       35 +/- 3 ng/ml, p = 0.003). Patients with established AIDS, who were
       afebrile and had no evidence of acute concurrent infection, had even
       higher sEs serum levels (70 +/- 9 ng/ml, p = 0.009, compared to those
       without AIDS). A significant increase in clinical category disease
       progression was present. Individual concentrations of sEs correlated
       directly with levels of soluble intercellular adhesion molecule-1 (p <
       0.00001) and IL-2 receptor (p = 0.001), but not with CD4+ T-cell counts.
       Zidovudine treatment was not associated with changes in sEs serum
       levels. Elevated sEs levels were also found in HIV-seronegative patients
       with other bacterial and protozoal infections. Since sEs is a
       biologically active molecule, further studies should investigate the
       pathogenetic significance of circulating sEs in HIV-related disease
       progression, and assess the prognostic value of sEs determination for
       these patients.
 DE    Acquired Immunodeficiency Syndrome/*BLOOD/IMMUNOLOGY  Adult  Aged
       Disease Progression  E-Selectin/*BLOOD  Female  Human  HIV
       Infections/*BLOOD/IMMUNOLOGY  Male  Middle Age  Support, Non-U.S. Gov't
       JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

