       Document 0140
 DOCN  M9630140
 TI    Cytomegalovirus viraemia in HIV infection: association with intercurrent
       infection.
 DT    9603
 AU    Evans MR; Booth JC; Wansbrough-Jones MH; Division of Infectious
       Diseases, St George's Hospital Medical; School, London, U.K.
 SO    J Infect. 1995 Jul;31(1):21-6. Unique Identifier : AIDSLINE MED/96019120
 AB    The aim of this retrospective study was to investigate the clinical
       significance of cytomegalovirus (CMV) viraemia in HIV-infected subjects
       (with or without AIDS) who had attended this hospital during a 45 month
       period. They were reviewed regularly and, when clinically indicated,
       tested for CMV viraemia. The blood of 105 subjects was cultured for CMV
       and 34 had at least one episode of CMV viraemia during the review
       period. The viraemia was present during CMV disease in nine of the 34
       positive patients and was the only detectable infection in another two.
       In the remaining 23 patients, CMV viraemia occurred in association with
       intercurrent opportunistic infection. Among these 23 patients, the
       viraemia resolved in 12 after treatment (or natural resolution) of the
       intercurrent infection and only one of these 12 developed CMV disease
       (mean review period: 8 months). In another seven patients, CMV viraemia
       persisted despite treatment (or natural resolution) of the intercurrent
       infection and four subsequently developed CMV disease (mean review
       period: 4 months) (P = 0.08, Fisher's exact test). From the remaining
       four patients, no specimens for CMV culture were obtained after
       treatment of the intercurrent infection. The CD4 count was higher in the
       12 patients in whom there was resolution of the viraemia [mean CD4 60 x
       10(6)/l] compared with the seven in whom the viraemia persisted [mean
       CD4 45 x 10(6)/l]. These findings suggest that in some HIV-positive
       patients, CMV viraemia was potentiated by intercurrent infection with
       another micro-organism and that its treatment was sufficient to mitigate
       the CMV disease.
 DE    AIDS-Related Opportunistic Infections/*COMPLICATIONS  Comparative Study
       Cytomegalovirus Infections/*COMPLICATIONS  Human  HIV
       Infections/*COMPLICATIONS  Retrospective Studies  Time Factors
       Viremia/*COMPLICATIONS  Virology/METHODS  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

