       Document 0131
 DOCN  M9630131
 TI    Increased brain levels of platelet-activating factor in a murine
       acquired immune deficiency syndrome are NMDA receptor-mediated.
 DT    9603
 AU    Nishida K; Markey SP; Kustova Y; Morse HC 3rd; Skolnick P; Basile AS;
       Sei Y; Section on Analytical Biochemistry, National Institute of Mental;
       Health, National Institutes of Health, Bethesda, Maryland 20892,; USA.
 SO    J Neurochem. 1996 Jan;66(1):433-5. Unique Identifier : AIDSLINE
       MED/96102965
 AB    Mice infected with the LP-BM5 murine leukemia virus (MuLV) develop an
       immunodeficiency syndrome (murine AIDS) and an encephalopathy
       characterized by impaired spatial learning and memory. Because
       platelet-activating factor (PAF) has been implicated in the pathogenesis
       of HIV-associated dementia complex, brain PAF levels were measured in
       LP-BM5 MuLV-infected mice. PAF levels in cerebral cortex and hippocampus
       were significantly increased at 6 and 12 weeks after LP-BM5 MuLV
       inoculation, whereas significant increases in striatal and cerebellar
       PAF levels were observed only at 12 weeks after inoculation.
       Administration of the NMDA antagonist MK-801 significantly reduced the
       increased PAF levels in the cerebral cortex and hippocampus of LP-BM5
       MuLV-infected mice. These results indicate that the LP-BM5 MuLV-induced
       increases in brain PAF levels are the results of NMDA receptor
       activation and are consistent with the hypothesis that elevated CNS PAF
       levels contribute to the behavioral deficits observed in LP-BM5
       MuLV-infected mice.
 DE    Animal  AIDS Dementia Complex/*METABOLISM  Behavior, Animal/PHYSIOLOGY
       *Brain Chemistry  *Disease Models, Animal  Dizocilpine
       Maleate/PHARMACOLOGY  Excitatory Amino Acid Antagonists/PHARMACOLOGY
       Human  Mice  Mice, Inbred C57BL  Murine Acquired Immunodeficiency
       Syndrome/*METABOLISM  Platelet Activating Factor/*BIOSYNTHESIS/GENETICS
       Receptors, N-Methyl-D-Aspartate/*PHYSIOLOGY  JOURNAL ARTICLE

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

