       Document 0128
 DOCN  M9630128
 TI    Primary central nervous system lymphomas--new pathological developments.
 DT    9603
 AU    Jellinger KA; Paulus W; Ludwig Boltzmann Institute of Clinical
       Neurobiology, Laniz; Hospital, Vienna, Austria.
 SO    J Neurooncol. 1995;24(1):33-6. Unique Identifier : AIDSLINE MED/96131091
 AB    Primary central nervous system lymphomas (PCNSL) show increased
       incidence both in immunocompromised high-risk groups and in the general
       population. They are extranodal diffuse non-Hodgkin's lymphomas with a
       morphology similar to systemic lymphomas, but differ in their biological
       and molecular behaviour. The majority are large B-cell variants of
       high-grade malignancy; low-grade subtypes and T-cell lymphomas are rare;
       up to 50% remain unclassified according to the New Working Formulation
       and updated Kiel classification. Monoclonality of immunoglobulin
       receptor gene rearrangement can be diagnostically useful. The
       pathogenesis of PCNSL is obscure. Epstein-Barr virus (EBV)
       genome/proteins expression in two-thirds of HIV-related PCNSL but only
       in 15% of those in immunocompetent patients suggest different EBV
       latency stages in both types; human herpesvirus type 6 does not appear
       to play a pathogenic role. Comparison of expression patterns of integrin
       chains and adhesion molecules are very similar for PCNSL and nodal
       lymphomas suggesting that they are not selective mediators of lymphoma
       cell homing to the brain. In HIV-negative PCNSL they appear not to be
       influenced by EBV. Studies of protooncogenes (bcl-1 and bcl-2 genes)
       revealed no rearrangement in PCNSL, suggesting that they are not
       involved in the pathogenesis of PCNSL that probably do not differ
       cytogenetically from nodal B-cell lymphomas. Since most of the currently
       known molecular parameters are probably not the primary pathogenic
       events, the molecular genetics and pathogenesis of PCNSL are still to be
       elucidated.
 DE    Cell Adhesion Molecules/PHYSIOLOGY  Central Nervous System
       Neoplasms/EPIDEMIOLOGY/ETIOLOGY/*PATHOLOGY  Human  Incidence
       Lymphoma/EPIDEMIOLOGY/ETIOLOGY/*PATHOLOGY  Proto-Oncogenes  Risk Factors
       JOURNAL ARTICLE  REVIEW  REVIEW, TUTORIAL

       SOURCE: National Library of Medicine.  NOTICE: This material may be
       protected by Copyright Law (Title 17, U.S.Code).

